Schleiffer R, Berthelot A, Pernot F, Gairard A
Jpn Circ J. 1981 Nov;45(11):1272-9. doi: 10.1253/jcj.45.1272.
Parathyroid glands play a significant role in the development of hypertension in spontaneously hypertensive rat (SHR), like in deoxycorticosterone acetate (DOCA) + NaCl model. Parathyroidectomy (PTX) performed after weaning delayed systolic blood pressure (SBP) increase and slowed heart rate (HR) in SHR for 42 weeks. These changes could not be attributed to decrease of serum calcium in PTX animals since supplementation of calcium, rendering serum calcium normal, did not reestablish SBP and HR to those of sham SHR. Moreover, in the thyroparathyroidectomized (TPTX) animals SBP and HR were increased by autotransplantation of parathyroids. When hypertension was established (week 15), PTX produced no more changes on cardiovascular parameters measured. These data clearly indicate that independent of thyroidectomy, PTX leads to a lesser degree of hypertension in young SHR, but was without effect on established hypertension. In conclusion, parathyroid glands are required for total development of the hypertensive process in SHR.
甲状旁腺在自发性高血压大鼠（SHR）的高血压发展过程中发挥着重要作用，就像在醋酸脱氧皮质酮（DOCA）+氯化钠模型中一样。断奶后进行甲状旁腺切除术（PTX）可使SHR的收缩压（SBP）升高延迟，并使心率（HR）在42周内减缓。这些变化不能归因于PTX动物血清钙的降低，因为补充钙使血清钙正常后，并未使SBP和HR恢复到假手术SHR的水平。此外，在甲状腺甲状旁腺切除（TPTX）的动物中，甲状旁腺的自体移植会使SBP和HR升高。当高血压形成时（第15周），PTX对所测量的心血管参数不再产生影响。这些数据清楚地表明，独立于甲状腺切除术，PTX可使年轻SHR的高血压程度减轻，但对已形成的高血压没有影响。总之，甲状旁腺是SHR高血压过程完全发展所必需的。
