Schleiffer R, Pernot F, Gairard A
Clin Sci (Lond). 1986 Nov;71(5):505-11. doi: 10.1042/cs0710505.
In order to elucidate the mechanisms by which parathyroidectomy (PTX), performed in young spontaneously hypertensive rats (SHR), delays the development and attenuates the level of hypertension, we studied, in vivo, cardiovascular reactivity (CVR, blood pressure response to bolus noradrenaline administration), aortic calcium distribution and cardiac calcium content in SHR with or without parathyroid glands. PTX was performed in 6-week-old animals and experiments were done in pretreated anaesthetized animals 2 and 22 weeks after surgery. A significantly decreased CVR was observed 22 weeks after PTX in SHR-PTX as compared with controls. These data are not specific for hypertensive animals since similar data are also obtained on normotensive Wistar rats treated in an identical fashion. In addition, after PTX in SHR and Wistar rats myocardial (auricle and ventricle) calcium content was more rapidly reduced (after 2 weeks) than aortic membrane-bound and cellular calcium fractions. The present studies established that PTX decreased CVR and alters calcium content and distribution in the cardiovascular systems of rats from hypertensive and normotensive strains. Furthermore, the results confirm a requirement for the parathyroid glands in the pathogenesis of spontaneous hypertension in SHR and for the normal CVR.
为了阐明在年轻的自发性高血压大鼠（SHR）中进行甲状旁腺切除术（PTX）可延缓高血压发展并减轻高血压程度的机制，我们在体内研究了有或没有甲状旁腺的SHR的心血管反应性（CVR，推注去甲肾上腺素后的血压反应）、主动脉钙分布和心脏钙含量。在6周龄动物中进行PTX，并在术后2周和22周对预处理的麻醉动物进行实验。与对照组相比，SHR-PTX在PTX后22周观察到CVR显著降低。这些数据并非高血压动物所特有，因为以相同方式处理的正常血压Wistar大鼠也获得了类似的数据。此外，在SHR和Wistar大鼠中进行PTX后，心肌（心房和心室）钙含量比主动脉膜结合钙和细胞钙部分更快地降低（2周后）。本研究证实，PTX降低了CVR，并改变了高血压和正常血压大鼠品系大鼠心血管系统中的钙含量和分布。此外，结果证实了甲状旁腺在SHR自发性高血压发病机制和正常CVR中的必要性。
