Aoki K, Kondo S, Sato K, Kato K, Kawaguchi Y, Mochizuki A, Yamamoto M
Jpn Heart J. 1981 Jul;22(4):575-84. doi: 10.1536/ihj.22.575.
The hypotensive effect of nifedipine (a Ca2+-antagonist) was studied in acute tests and during the long-term administration of the drug together with propranolol. Nifedipine (10 mg, sublingually) decreased blood pressure from 174/102 to 136/82 mmHg with increase in heart rate and plasma renin activity. The combination of nifedipine (10 mg, sublingually) and propranolol (0.2 mg/Kg body weight, intravenously) decreased blood pressure from 168/104 to 131/86 mmHg with decrease in heart rate and plasma renin activity. Twenty-five hypertensive patients were treated with nifedipine and propranolol (10 mg x 3 to 4/day) together with or without diuretic for long-term. With the combination therapy, blood pressure of Group I (11 hypertensive patients with coronary heart disease) fell from 211/129 to 140/85 mmHg, blood pressure of Group II (9 severe hypertensive patients without coronary heart disease) from 230/137 to 139/84 mmHg, and blood pressure of Group III (5 established hypertension) from 182/107 to 134/83 mmHg. With this treatment regimen, heart rate and plasma renin activity decreased, and abnormal electrocardiographic findings, hypertensive retinopathy, and renal dysfunction were improved. Nifedipine, in combination with propranolol and a diuretic, is considered an effective treatment of hypertension either with or without coronary heart disease.
在急性试验以及硝苯地平（一种钙拮抗剂）与普萘洛尔联合长期给药期间，研究了其降压作用。硝苯地平（10毫克，舌下含服）使血压从174/102毫米汞柱降至136/82毫米汞柱，同时心率和血浆肾素活性增加。硝苯地平（10毫克，舌下含服）与普萘洛尔（0.2毫克/千克体重，静脉注射）联合使用使血压从168/104毫米汞柱降至131/86毫米汞柱，同时心率和血浆肾素活性降低。25例高血压患者长期接受硝苯地平和普萘洛尔（10毫克×3至4次/天）治疗，联合或不联合利尿剂。联合治疗时，第一组（11例冠心病高血压患者）血压从211/129毫米汞柱降至140/85毫米汞柱，第二组（9例无冠心病的重度高血压患者）血压从230/137毫米汞柱降至139/84毫米汞柱，第三组（5例确诊高血压患者）血压从182/107毫米汞柱降至134/83毫米汞柱。采用这种治疗方案，心率和血浆肾素活性降低，异常心电图表现、高血压视网膜病变和肾功能障碍得到改善。硝苯地平与普萘洛尔及利尿剂联合使用，被认为是治疗伴有或不伴有冠心病的高血压的有效方法。
