Moqbel R, Wakelin D
Parasite Immunol. 1981 Autumn;3(3):181-9. doi: 10.1111/j.1365-3024.1981.tb00397.x.
Adoptive transfer of immunity against the enteral phase of Strongyloides ratti was monitored using four parameters; namely, number of worms recovered, position occupied in the host's small intestine, worm length and fecundity. When immune mesenteric lymph node cells (IMLNC) were transferred from donors infected for 20, 26 or 32 days into recipients infected for 3 days, a marked acceleration of worm expulsion was evident by day 16 post-infection (p.i.). IMLNC from day-16 p.i. donors did not transfer expulsion. In an experiment in which recipients were given 2 x 10(8) or 1 x 10(8) IMLNC from donors infected for 26 days, accelerated worm expulsion occurred only with the higher inoculum, although manifestations of direct worm immunity, i.e. altered position and reduced length and fecundity, were evident in both cases. Transfer of IMLNC appeared to have no effect upon worm establishment; when cells were transferred on the day of infection a period of 16 days was necessary to effect both direct anti-worm immunity and expulsion, although the former was evident on day 14 p.i. However, when IMLNC were transferred to rats already infected for 6 days, a very significant reduction of their worm burden was apparent 10 days after IMLNC transfer.
利用四个参数监测针对鼠类类圆线虫肠内阶段的免疫过继转移；即回收的蠕虫数量、在宿主小肠中占据的位置、蠕虫长度和繁殖力。当将来自感染20、26或32天的供体的免疫肠系膜淋巴结细胞（IMLNC）转移到感染3天的受体中时，在感染后第16天（p.i.）明显出现蠕虫排出加速。来自感染后第16天供体的IMLNC未转移排出作用。在一项实验中，给受体注射来自感染26天供体的2×10⁸或1×10⁸个IMLNC，仅在接种量较高时出现蠕虫排出加速，尽管在两种情况下直接蠕虫免疫的表现，即位置改变、长度和繁殖力降低都很明显。IMLNC的转移似乎对蠕虫定植没有影响；当在感染当天转移细胞时，需要16天才能产生直接抗蠕虫免疫和排出作用，尽管前者在感染后第14天就很明显。然而，当将IMLNC转移到已经感染6天的大鼠中时，在转移IMLNC 10天后，它们的蠕虫负荷显著降低。
