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通过与中国仓鼠细胞共培养抑制布卢姆综合征成纤维细胞中姐妹染色单体交换的频率。

Suppression of the frequencies of sister chromatid exchanges in Bloom's syndrome fibroblasts by co-cultivation with Chinese hamster cells.

作者信息

van Buul P P, Natarajan A T, Verdegaal-Immerzeel E A

出版信息

Hum Genet. 1978 Oct 31;44(2):187-9. doi: 10.1007/BF00295412.

DOI:10.1007/BF00295412
PMID:730162
Abstract

The effect of co-cultivation of Bloom's syndrome fibroblasts with Chinese hamster ovary cells (CHO) on the incidence of sister chromatid exchanges (SCEs) was studied. The results show that suppression of the frequency of SCEs in Bloom's syndrome cells occurs only if cell to cell contact is present with CHO cells, without any effect on the SCE frequency in the latter. It is suggested that possible genetic heterogeneity between different Bloom's syndrome patients can be studied using the method of co-cultivation.

摘要

研究了布卢姆综合征成纤维细胞与中国仓鼠卵巢细胞（CHO）共培养对姐妹染色单体交换（SCE）发生率的影响。结果表明，仅当布卢姆综合征细胞与CHO细胞存在细胞间接触时，布卢姆综合征细胞中SCE的频率才会受到抑制，而对后者的SCE频率没有任何影响。有人提出，可以使用共培养方法研究不同布卢姆综合征患者之间可能存在的遗传异质性。

相似文献

1
Suppression of the frequencies of sister chromatid exchanges in Bloom's syndrome fibroblasts by co-cultivation with Chinese hamster cells.通过与中国仓鼠细胞共培养抑制布卢姆综合征成纤维细胞中姐妹染色单体交换的频率。
Hum Genet. 1978 Oct 31;44(2):187-9. doi: 10.1007/BF00295412.
2
A manyfold increase in sister chromatid exchanges in Bloom's syndrome lymphocytes.布卢姆综合征淋巴细胞中姐妹染色单体交换的多重增加。
Proc Natl Acad Sci U S A. 1974 Nov;71(11):4508-12. doi: 10.1073/pnas.71.11.4508.
3
High rate of sister chromatid exchanges of Bloom's syndrome chromosomes is corrected in rodent human somatic cell hybrids.布卢姆综合征染色体的姐妹染色单体交换高发生率在啮齿动物-人类体细胞杂种中得到纠正。
Cytogenet Cell Genet. 1980;27(1):8-23. doi: 10.1159/000131459.
4
Increased sister chromatid exchange in bone marrow and blood cells from Bloom's syndrome.布卢姆综合征患者骨髓和血细胞中姐妹染色单体交换增加。
Cytogenet Cell Genet. 1976;17(4):162-73. doi: 10.1159/000130710.
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Sister chromatid exchange and cell cycle in fibroblasts of Bloom's syndrome.布卢姆综合征成纤维细胞中的姐妹染色单体交换与细胞周期
Hum Genet. 1979 Apr 17;48(1):73-9. doi: 10.1007/BF00273277.
6
Effects of mitomycin C on sister chromatid exchange in normal and Bloom's syndrome cells.丝裂霉素C对正常细胞和布卢姆综合征细胞中姐妹染色单体交换的影响。
Mutat Res. 1978 Feb;49(2):233-8. doi: 10.1016/0027-5107(78)90162-8.
7
The relationship between sister chromatid exchanges and chromosome aberrations in Bloom's syndrome.布卢姆综合征中姐妹染色单体交换与染色体畸变之间的关系。
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Effect of cocultivation on sister chromatid exchange frequencies in Bloom's syndrome and normal fibroblast cells.共培养对布卢姆综合征和正常成纤维细胞中姐妹染色单体交换频率的影响。
Nature. 1978 Jun 15;273(5663):538-40. doi: 10.1038/273538a0.
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Rate of sister chromatid exchanges in Bloom syndrome fibroblasts reduced by co-cultivation with normal fibroblasts.通过与正常成纤维细胞共培养，布卢姆综合征成纤维细胞中姐妹染色单体交换率降低。
Am J Hum Genet. 1980 Mar;32(2):150-7.
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Bloom's syndrome: in vitro correction of the sister chromatid exchange rate by normal cells.布卢姆综合征：正常细胞对姐妹染色单体交换率的体外校正
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引用本文的文献

1
Sister chromatid exchange in vivo, chromosomal characterization and NORs activity of leukemia cells during 5FU-treatments.体内姐妹染色单体交换、白血病细胞染色体特征和 5FU 治疗期间 NORs 活性。
Theor Appl Genet. 1987 Jun;74(2):247-52. doi: 10.1007/BF00289976.
2
Rate of sister chromatid exchanges in Bloom syndrome fibroblasts reduced by co-cultivation with normal fibroblasts.通过与正常成纤维细胞共培养，布卢姆综合征成纤维细胞中姐妹染色单体交换率降低。
Am J Hum Genet. 1980 Mar;32(2):150-7.
3
Effect of incubation temperature on the frequency of sister chromatid exchanges in Bloom's syndrome lymphocytes.

本文引用的文献

1
CHROMOSOMAL BREAKAGE IN A RARE AND PROBABLY GENETICALLY DETERMINED SYNDROME OF MAN.人类一种罕见且可能由基因决定的综合征中的染色体断裂
Science. 1965 Apr 23;148(3669):506-7. doi: 10.1126/science.148.3669.506.
2
Transfer of cytoplasmic and nuclear proteins between cells in culture.培养细胞间细胞质和核蛋白的转移。
J Mol Biol. 1973 Jun 25;78(1):197-210. doi: 10.1016/0022-2836(73)90438-5.
3
Genetic heterogeneity of xeroderma pigmentosum demonstrated by somatic cell hybridization.通过体细胞杂交证明的着色性干皮病的遗传异质性。
孵育温度对布卢姆综合征淋巴细胞中姐妹染色单体交换频率的影响。
Hum Genet. 1981;59(3):204-7. doi: 10.1007/BF00283664.
4
Functional deficiency of fibroblasts heterozygous for Bloom syndrome as specific manifestation of the primary defect.布鲁姆综合征杂合子成纤维细胞的功能缺陷作为原发性缺陷的特异性表现。
Am J Hum Genet. 1981 Nov;33(6):928-34.
5
Antagonistic effect of cocultivation on mitomycin C-induced aberration rate in cells of a patient with Fanconi's anemia and in Chinese hamster ovary cells.共培养对范可尼贫血患者细胞及中国仓鼠卵巢细胞中丝裂霉素C诱导的畸变率的拮抗作用。
Hum Genet. 1980;56(1):85-8. doi: 10.1007/BF00281574.
6
Chromosome breakage factor in the plasma of two Bloom's syndrome patients.两名布卢姆综合征患者血浆中的染色体断裂因子。
Hum Genet. 1982;61(1):65-7. doi: 10.1007/BF00291336.
7
Sister chromatid exchange analysis.
Am J Hum Genet. 1980 May;32(3):297-313.
8
Prenatal recognition of a defect in DNA repair.产前对DNA修复缺陷的识别。
Mol Gen Genet. 1981;184(1):17-9. doi: 10.1007/BF00271188.
9
Clastogenic activity from Bloom syndrome fibroblast cultures.布卢姆综合征成纤维细胞培养物的致断裂活性。
Proc Natl Acad Sci U S A. 1981 Mar;78(3):1868-72. doi: 10.1073/pnas.78.3.1868.
10
Cell cycle rate and sister chromatid exchange profile in polyethylene glycol-exposed/unexposed Bloom syndrome and normal cells. A co-culture study.聚乙二醇暴露/未暴露的布卢姆综合征细胞和正常细胞中的细胞周期速率及姐妹染色单体交换谱。一项共培养研究。
Hum Genet. 1987 Apr;75(4):356-8. doi: 10.1007/BF00284107.
Nat New Biol. 1972 Jul 19;238(81):80-3. doi: 10.1038/newbio238080a0.
4
A manyfold increase in sister chromatid exchanges in Bloom's syndrome lymphocytes.布卢姆综合征淋巴细胞中姐妹染色单体交换的多重增加。
Proc Natl Acad Sci U S A. 1974 Nov;71(11):4508-12. doi: 10.1073/pnas.71.11.4508.
5
New Giemsa method for the differential staining of sister chromatids.用于姐妹染色单体鉴别染色的新吉姆萨方法。
Nature. 1974 Sep 13;251(5471):156-8. doi: 10.1038/251156a0.
6
Evidence for transfer of macromolecular RNA between mammalian cells in culture.培养的哺乳动物细胞间大分子RNA转移的证据。
Exp Cell Res. 1971 Apr;65(2):313-24. doi: 10.1016/0014-4827(71)90007-3.
7
Progeria cells are stimulated to repair DNA by co-cultivation with normal cells.早衰细胞通过与正常细胞共培养来刺激修复DNA。
Exp Cell Res. 1976 Feb;97(2):291-6. doi: 10.1016/0014-4827(76)90619-4.
8
Bloom's syndrome. IV. Sister-chromatid exchanges in lymphocytes.布卢姆综合征。IV. 淋巴细胞中的姐妹染色单体交换
Am J Hum Genet. 1977 May;29(3):248-55.