Bieniek K
Pol Arch Weter. 1981;23(1):103-6.
The investigations were performed on 6 Friesian-Holstein heifers, weighing 410-504 kg, in which acid indigestion was induced by intraruminal administration of saccharose in a dose of 12 g/kg body weight. The animals were observed for 9 days after the treatment. Functional state of the liver was evaluated on the basis of bromosulphthalein clearance, total bilirubin level and aspartate amino-transferase (AspAT) activity in serum, concentration of blood glucose, total serum protein and protein fractions. Within the first 24 hours, all heifers developed acute symptoms of rumen acidosis which persisted for 3 days after saccharose administration. Afterwards, a phase of gradual spontaneous recovery was observed. In the course of rumen acidosis a reduction in bromosulphthalein clearance, an increase in bilirubin level and AspAT activity, a decrease and then an increase in glucose concentration and a reduction in albumin content and, as a consequence, in albumin/globulin ratio were found. The results indicate that experimental rumen acidosis produced disturbances in excretory and metabolic functions of the liver in the examined heifers. Changes in biochemical parameters were preceded by an increase in AspAT activity and were most remarkable between 48 and 144 hours after saccharose administration. Liver dysfunction was of a various degree in individual animals and recovered within a relatively short period following the disappearance of rumen acidosis symptoms.
对6头体重410 - 504千克的弗里斯兰 - 荷斯坦小母牛进行了研究，通过向瘤胃内注射剂量为12克/千克体重的蔗糖来诱发酸消化不良。处理后对这些动物观察了9天。基于血清中溴磺酞钠清除率、总胆红素水平、天冬氨酸氨基转移酶（AspAT）活性、血糖浓度、血清总蛋白和蛋白组分来评估肝脏的功能状态。在最初的24小时内，所有小母牛都出现了瘤胃酸中毒的急性症状，这些症状在给予蔗糖后持续了3天。之后，观察到一个逐渐自发恢复的阶段。在瘤胃酸中毒过程中，发现溴磺酞钠清除率降低、胆红素水平和AspAT活性升高、葡萄糖浓度先降低后升高，以及白蛋白含量降低，结果白蛋白/球蛋白比值也降低。结果表明，实验性瘤胃酸中毒在被检查的小母牛中引起了肝脏排泄和代谢功能的紊乱。生化参数的变化在AspAT活性升高之后出现，并且在给予蔗糖后48至144小时之间最为明显。肝脏功能障碍在个体动物中程度各异，并在瘤胃酸中毒症状消失后的相对较短时间内恢复。
