Agnoli A, Martucci N, Baldassare M, Polleri A
Rev Electroencephalogr Neurophysiol Clin. 1981 Jul-Sep;10(3):242-8. doi: 10.1016/s0370-4475(80)80006-2.
Measurement of plasma prolactin levels in elderly subjects demonstrated the presence of a hyperprolactinemia with loss of normal circadian rhythm, regressing after bromocriptine treatment. The administration of bromocriptine to elderly subjects in a normal state of health provokes marked changes in the E.E.G. spectrum (slowing of delta activity, increase in alpha and decrease in beta rhythms). These findings show that there is an alteration in central dopaminergic systems during aging.
对老年受试者血浆催乳素水平的测量表明存在高催乳素血症，且正常昼夜节律丧失，经溴隐亭治疗后恢复正常。对健康状态正常的老年受试者给予溴隐亭会引起脑电图频谱的显著变化（δ活动减慢，α波增加，β节律减少）。这些发现表明衰老过程中中枢多巴胺能系统发生了改变。
