Belvedere G, Tursi F
Res Commun Chem Pathol Pharmacol. 1981 Aug;33(2):273-82.
Human erythrocytes and lymphocytes catalyzed styrene oxidation to styrene oxide. The erythrocyte catalyzed reaction was inhibited by CO, occurred in the absence of NADPH and NADH and was undetectable in the absence of O2 and with erythrocyte membranes. Lymphocyte catalyzed styrene oxide formation required the addition of cofactors and these cells showed 6 times the activity of erythrocytes with a 4 times lower styrene concentration. Although lymphocytes appear to be more active than red blood cells in styrene oxidation, their contribution to styrene metabolism in whole blood seems extremely small.
人类红细胞和淋巴细胞可催化苯乙烯氧化生成环氧苯乙烯。红细胞催化的反应受到一氧化碳的抑制，在没有烟酰胺腺嘌呤二核苷酸磷酸（NADPH）和烟酰胺腺嘌呤二核苷酸（NADH）的情况下发生，并且在没有氧气以及没有红细胞膜的情况下无法检测到。淋巴细胞催化生成环氧苯乙烯需要添加辅因子，这些细胞在苯乙烯浓度低4倍的情况下，活性是红细胞的6倍。尽管淋巴细胞在苯乙烯氧化中似乎比红细胞更活跃，但它们对全血中苯乙烯代谢的贡献似乎极小。
