Pohlová H, Rössner P, Srám R J
J Hyg Epidemiol Microbiol Immunol. 1984;29(3):269-74.
Styrene and styrene oxide mutagenicity was tested in cultured human lymphocytes treated in vitro with various concentrations of test agents. Styrene alone was found mutagenic at the highest concentration used (5 X 10(-4) mol. l-1, combined with the alkylating agent THIO-TEPA it did not affect the chromosome aberration yield. Exposure to styrene oxide gave a positive result showing a clear-cut dose-effect relationship within the concentration range 5 X 10(-6) to 1 X 10(-3) mol. l-1. In combination with THIO-TEPA its effect on chromosome aberration yields was additive. Styrene oxide proved also to be a very potent inducer of sister chromatid exchanges (SCE) within the concentration range 5 X 10(-6) to 1 X 10(-3) mol. l-1 tested. Combined with THIO-TEPA it exhibited a distinct additive effect in the production of SCEs.
用不同浓度的测试剂体外处理培养的人淋巴细胞，对苯乙烯和环氧苯乙烷的致突变性进行了测试。单独使用苯乙烯时，在所使用的最高浓度（5×10⁻⁴摩尔·升⁻¹）下发现具有致突变性，与烷基化剂噻替派联合使用时，它不影响染色体畸变率。暴露于环氧苯乙烷产生了阳性结果，在5×10⁻⁶至1×10⁻³摩尔·升⁻¹的浓度范围内呈现出明显的剂量效应关系。与噻替派联合使用时，其对染色体畸变率的影响是相加的。在测试的5×10⁻⁶至1×10⁻³摩尔·升⁻¹浓度范围内，环氧苯乙烷也被证明是姐妹染色单体交换（SCE）的非常有效的诱导剂。与噻替派联合使用时，它在SCE的产生中表现出明显的相加效应。
