Turek Z, Kreuzer F
Respir Physiol. 1981 Aug;45(2):133-9. doi: 10.1016/0034-5687(81)90055-4.
The effect of a shift of the blood O2 dissociation curve (ODC) on the alveolar-arterial O2 gradient was studied in computer models of the lung with several degrees of VA/Q inequality during air breathing. A shift to the left decreases and a shift to the right increases not only the mixed-venous but also the arterial PO2. Consequently the alveolar-arterial O2 gradient is larger with a left and smaller with a right shift of the ODC. This effect of a shift of the ODC on the alveolar-arterial O2 gradient is negligible in a healthy lung but becomes quite considerable in a diseased lung with a severe mismatching of VA/Q.
在空气呼吸时，针对具有不同程度通气/血流比（VA/Q）失衡的肺脏计算机模型，研究了血液氧解离曲线（ODC）移动对肺泡-动脉血氧梯度的影响。曲线左移不仅会降低混合静脉血氧分压，也会降低动脉血氧分压；而曲线右移不仅会升高混合静脉血氧分压，也会升高动脉血氧分压。因此，ODC左移时肺泡-动脉血氧梯度更大，右移时则更小。在健康肺脏中，ODC移动对肺泡-动脉血氧梯度的这种影响可忽略不计，但在VA/Q严重不匹配的患病肺脏中，这种影响就会变得相当显著。
