Guilleminault C, Briskin J G, Greenfield M S, Silvestri R
Sleep. 1981 Sep;4(3):263-78. doi: 10.1093/sleep/4.3.263.
Ten patients with autonomic nervous system dysfunction (familial dysautonomia, juvenile diabetes, or Shy-Drager syndrome) were studied to assess the impact of their impairment on breathing during sleep. Several types of breathing dysfunction during sleep were identified independent of the patients' primary complaints. Obstructive sleep apnea syndrome was the most common; central sleep apnea and disturbances of te respiratory oscillator also were seen. Esophageal reflux was found to be the cause of some sleep-related problems. The observed respiratory irregularities were not associated with the usual cardiac response; a "decoupling" of heart rate from the respiratory cycle was noted during sleep in these patients.
对10名患有自主神经系统功能障碍（家族性自主神经功能异常、青少年糖尿病或夏伊-德雷格综合征）的患者进行了研究，以评估其功能损害对睡眠期间呼吸的影响。识别出了几种睡眠期间的呼吸功能障碍类型，这些类型与患者的主要症状无关。阻塞性睡眠呼吸暂停综合征最为常见；也观察到了中枢性睡眠呼吸暂停和呼吸振荡器紊乱。发现胃食管反流是一些睡眠相关问题的原因。观察到的呼吸不规则与通常的心脏反应无关；在这些患者睡眠期间，注意到心率与呼吸周期“脱耦”。
