Gadoth N, Sokol J, Lavie P
J Neurol Sci. 1983 Jul;60(1):117-25. doi: 10.1016/0022-510x(83)90131-4.
In 13 patients with familial dysautonomia sleep recordings were obtained to investigate the possibility that autonomic nervous system dysfunction plays a role in disordered breathing during sleep. Sleep structure in some of our patients was abnormal, showing decreased amount of REM sleep and increased REM latencies. All patients showed breathing disorders in sleep. The average number of apneic spells was 73.4 per night; 77% of the patients had more than 50 apneic spells per night. Abnormal breathing patterns were not uniform and were independent of patient's primary complaints. Typically, even severe respiratory irregularities were not associated with the usual cardiac response, indicating that our patients had "cardiac dysautonomia".
对13例家族性自主神经功能异常患者进行了睡眠记录，以研究自主神经系统功能障碍在睡眠呼吸紊乱中是否起作用。我们的一些患者睡眠结构异常，表现为快速眼动睡眠量减少和快速眼动潜伏期延长。所有患者睡眠中均出现呼吸障碍。每晚呼吸暂停发作的平均次数为73.4次；77%的患者每晚呼吸暂停发作超过50次。异常呼吸模式并不一致，且与患者的主要症状无关。通常，即使是严重的呼吸不规则也与常见的心脏反应无关，这表明我们的患者存在“心脏自主神经功能异常”。
