Sugawara C, Sugawara N, Miyake H
Toxicol Lett. 1981 Aug;8(6):323-9. doi: 10.1016/0378-4274(81)90121-1.
Male rats of the Wistar strain were injected subcutaneously with a total dose of 4.5 mg cadmium (Cd) per kg body weight. The first groups (Sc-1) was injected with 18 doses of 0.25 mg/kg, the second group (Sc-II) was injected with 9 doses of 0.50 mg/kg, and the third group (Sc-III) with 2 doses of 2.25 mg/kg. Another group was given water containing 75 ppm Cd for 68 days and 50 ppm for the ensuing 75 days. The plasma concentration of vitamin A (VA) was statistically decreased by the subcutaneous injections of Cd, but the liver concentration of VA was not altered. The fractionated injection of the total Cd apparently reduced the toxicity of Cd on VA metabolism. The decrease of plasma albumin was highly correlated with the decrease of plasma VA. The relative coefficient between them was calculated as 0.812 (n = 34, P less than 0.01) with all of the groups. the relative coefficient between plasma VA and zinc (Zn) was lower than that between plasma VA and albumin but was statistically significant (r = 0.697, P less than 0.01). These results may indicate the involvement of hepatic damage in Cd intoxications. The decrease of plasma VA, however, could not be explained by the Zn deficiency of the liver. To clarify the role of Zn in VA metabolism, the secretion mechanisms of them should be investigated in the liver.
将Wistar品系的雄性大鼠皮下注射，每千克体重注射总量为4.5毫克的镉（Cd）。第一组（Sc - 1）注射18次，每次0.25毫克/千克；第二组（Sc - II）注射9次，每次0.50毫克/千克；第三组（Sc - III）注射2次，每次2.25毫克/千克。另一组大鼠饮用含75 ppm镉的水68天，随后75天饮用含50 ppm镉的水。皮下注射镉使血浆维生素A（VA）浓度在统计学上降低，但肝脏中VA浓度未改变。镉总量的分次注射明显降低了镉对VA代谢的毒性。血浆白蛋白的降低与血浆VA的降低高度相关。所有组的两者之间的相关系数计算为0.812（n = 34，P小于0.01）。血浆VA与锌（Zn）之间的相关系数低于血浆VA与白蛋白之间的相关系数，但具有统计学意义（r = 0.697，P小于0.01）。这些结果可能表明肝脏损伤参与了镉中毒。然而，血浆VA的降低不能用肝脏锌缺乏来解释。为了阐明锌在VA代谢中的作用，应该在肝脏中研究它们的分泌机制。
