膳食锌或镉对大鼠和山羊毛发及组织矿物质浓度的影响。

Influence of dietary zinc or cadmium on hair and tissue mineral concentrations in rats and goats.

作者信息

Combs D K, Goodrich R D, Meiske J C

出版信息

J Anim Sci. 1983 Jan;56(1):184-93. doi: 10.2527/jas1983.561184x.

DOI:10.2527/jas1983.561184x

Abstract

Three experiments were conducted to determine whether concentrations of minerals in hair and other tissues of rats and goats are affected by level of dietary Zn or Cd. In the first experiment, rats were fed diets that contained 10.3, 20.5, 33.7, 41.3 or 52.9 micrograms Zn/g for 57 d. Rats fed the diet that contained 10.3 micrograms Zn/g suffered from mild Zn deficiency, as indicated by depressed feed intakes and slower growth rates than rats fed diets containing higher amounts of Zn. Zinc concentrations in hair (P less than .01), liver (P less than .01) and kidney (P less than .01) increased as dietary Zn increased. Confidence intervals for dietary Zn concentration predicted from Zn analysis of hair were large. In the second experiment, rats were fed diets that contained .1, 4.0, 7.6, 10.1 or 15.9 micrograms Cd/g for 57 d. Total growth, feed intake, feed efficiency and liver, kidney and testes weights were not affected (P greater than .05) by dietary Cd concentration. Cadmium increased linearly in liver (P less than .01) and kidney (P less than .01) and quadratically in testes (P less than .01) as Cd intake increased, but Cd in hair was not affected by dietary level of Cd. High correlations between Cd concentrations in liver (R2 = .88) and kidney (R2 = .90) and dietary Cd concentration indicate that Cd intakes of rats may be accurately predicted from Cd analyses of these tissues. In the third experiment, goats were fed diets containing 0, 10.4, 18.0 or 28.5 micrograms Cd/g for 125 d. Growth, feed intake, feed efficiency and liver and kidney weights were not affected by dietary Cd intake. Cadmium in hair samples was not affected by level of dietary Cd; however, cadmium in liver (P less than .01), kidney (P less than .01) and proximal duodenum (P less than .01) increased as dietary Cd increased. Cadmium in liver, kidney, lungs and proximal duodenum was highly correlated (R2 = .67, .89, .57, .49, respectively) with dietary Cd concentration.

摘要

进行了三项实验，以确定大鼠和山羊毛发及其他组织中的矿物质浓度是否受日粮锌或镉水平的影响。在第一项实验中，给大鼠喂食含锌量分别为10.3、20.5、33.7、41.3或52.9微克/克的日粮，持续57天。喂食含锌量为10.3微克/克日粮的大鼠出现轻度锌缺乏，表现为采食量下降，生长速度比喂食含锌量更高日粮的大鼠慢。随着日粮锌含量的增加，毛发（P<0.01）、肝脏（P<0.01）和肾脏（P<0.01）中的锌浓度升高。根据毛发锌分析预测的日粮锌浓度的置信区间较大。在第二项实验中，给大鼠喂食含镉量分别为0.1、4.0、7.6、10.1或15.9微克/克的日粮，持续57天。日粮镉浓度对总生长、采食量、饲料效率以及肝脏、肾脏和睾丸重量均无影响（P>0.05）。随着镉摄入量的增加，肝脏（P<0.01）和肾脏（P<0.01）中的镉呈线性增加，睾丸中的镉呈二次曲线增加（P<0.01），但毛发中的镉不受日粮镉水平的影响。肝脏（R²=0.88）和肾脏（R²=0.90）中的镉浓度与日粮镉浓度之间的高度相关性表明，可通过对这些组织的镉分析准确预测大鼠的镉摄入量。在第三项实验中，给山羊喂食含镉量分别为0、10.4、18.0或28.5微克/克的日粮，持续125天。日粮镉摄入量对生长、采食量、饲料效率以及肝脏和肾脏重量均无影响。毛发样本中的镉不受日粮镉水平的影响；然而，随着日粮镉含量的增加，肝脏（P<0.01）、肾脏（P<0.01）和十二指肠近端（P<0.01）中的镉含量增加。肝脏、肾脏、肺和十二指肠近端中的镉与日粮镉浓度高度相关（R²分别为0.67、0.89、0.57、0.49）。