扁桃体病变患者的免疫学考量

Immunological Considerations in patients with tonsillar lesions.

作者信息

Yamauchi S, Ikeda M, Ikeda M, Yoshida A, Okamoto K, Ozawa A

出版信息

Tokai J Exp Clin Med. 1981 Apr;6(2):181-92.

Abstract

No abolition of functions from the clinical aspect was detected in most patients with tonsillectomies or adenotomies although there are some reports that tonsillectomy increases the susceptibility to subsequent development of Hodgkin's disease by 2.9 fold. Sequential investigations on the responsiveness of lymphocytes to various mitogens, and quantitative estimations of immunoglobulins and other humoral factors were carried out in 54 tonsillectomized and/or adenotomized patients of either sex between the ages of 4 and 55. The present findings showed abnormalities in lymphocyte responses to mitogens and the production of humoral factors in a few young patients post operatively, although they were not detected in adult patients during sequential observations.

摘要

尽管有一些报告称扁桃体切除术会使后续患霍奇金病的易感性增加2.9倍，但在大多数接受扁桃体切除术或腺样体切除术的患者中，从临床角度未发现功能缺失。对54例年龄在4至55岁之间、接受过扁桃体切除术和/或腺样体切除术的男女患者进行了淋巴细胞对各种有丝分裂原反应性的系列研究，以及免疫球蛋白和其他体液因子的定量评估。目前的研究结果显示，少数年轻患者术后淋巴细胞对有丝分裂原的反应及体液因子的产生存在异常，不过在系列观察中成年患者未出现此类情况。