Endoh M, Kaneshige H, Tomino Y, Nomoto Y, Sakai H, Arimori S
Tokai J Exp Clin Med. 1981 Jul;6(3):327-31.
We experienced an 85-year-old male patient with selective IgM deficiency. The average levels of his serum immunoglobulins were as follows: IgG, 1,165 mg/dl, IgA 280 mg/dl, and IgM 17 mg/dl. The subpopulations of peripheral blood lymphocytes in this patient were normal, including normal numbers of IgM-bearing lymphocytes. Normal amounts of cells with cytoplasmic IgM were induced by in vitro addition of pokeweek mitogen, and no inhibitory cells or inhibitory factors for in vitro production of IgM were demonstrated in his blood. These results suggest that some defects similar to those in patients with selective IgA deficiency may play a role in the development of selective IgM deficiency.
我们遇到了一位85岁的选择性IgM缺乏男性患者。他血清免疫球蛋白的平均水平如下：IgG为1,165mg/dl，IgA为280mg/dl，IgM为17mg/dl。该患者外周血淋巴细胞亚群正常，包括带有IgM的淋巴细胞数量正常。体外添加商陆有丝分裂原可诱导出正常数量的细胞质IgM细胞，且在其血液中未发现抑制IgM体外产生的抑制细胞或抑制因子。这些结果表明，一些与选择性IgA缺乏患者相似的缺陷可能在选择性IgM缺乏的发生中起作用。
