Pozzato G, Perticarari S, Presani G, Luchesi A, Franzin F
Istituto di Patologia Medica dell'Università.
G Clin Med. 1990 Jun-Jul;71(6-7):427-32.
The ability of Interferon (IFN) alpha, beta and gamma to induce IgA production from IgA deficient patients lymphocytes was tested "in vitro". In affected patients IgG and IgM production was similar to the normal cases but no effect on IgA production was observed. In normal cases variable concentration of alpha- beta- and gamma-IFN resulted in different immunoglobulin production. In IgA selective deficiency a low number of SmIgA bearing cells and defective transformation in IgA-plasma cells was noted as possible primary defect.
对α、β和γ干扰素诱导IgA缺乏患者淋巴细胞产生IgA的能力进行了“体外”测试。在患病患者中，IgG和IgM的产生与正常情况相似，但未观察到对IgA产生有影响。在正常情况下，不同浓度的α、β和γ干扰素会导致不同的免疫球蛋白产生。在IgA选择性缺乏症中，发现携带SmIgA的细胞数量较少以及IgA浆细胞转化存在缺陷，这可能是主要缺陷。
