肥胖带绦虫感染中的免疫抑制：活化的腹腔细胞对绵羊红细胞体外反应的恢复。
Immunodepression in Taenia crassiceps infection: restoration of the in vitro response to sheep erythrocytes by activated peritoneal cells.
作者信息
Miller K L, Good A H, Mishell R I
出版信息
Infect Immun. 1978 Nov;22(2):365-70. doi: 10.1128/iai.22.2.365-370.1978.
The in vitro response to sheep erythrocytes of mesenteric lymph node cells from mice infected with the larval cestode Taenia crassiceps is significantly depressed and can be restored to control levels by addition of activated peritoneal cells depleted of functional T or B lymphocytes. Adherent mesenteric lymph node cells from infected mice are unable to reconstitute the in vitro response to sheep erythrocytes of normal nonadherent cells. The responses of mesenteric lymph node cells from infected mice to the T-lymphocyte mitogens concanavalin A and phytohemagglutinin and the B-lymphocyte mitogen lipopolysaccharide are normal. Mesenteric lymph node cells from infected mice do not suppress the in vitro response to sheep erythrocytes of normal mesenteric lymph node cells. These results suggest that the immunodepression in T. crassiceps-infected mice is primarily the result of alterations in functional accessory cells.
感染幼虫绦虫粗颈绦虫的小鼠肠系膜淋巴结细胞对绵羊红细胞的体外反应明显受到抑制，通过添加去除功能性T或B淋巴细胞的活化腹膜细胞可恢复到对照水平。感染小鼠的黏附性肠系膜淋巴结细胞无法重建正常非黏附细胞对绵羊红细胞的体外反应。感染小鼠的肠系膜淋巴结细胞对T淋巴细胞有丝分裂原刀豆球蛋白A和植物血凝素以及B淋巴细胞有丝分裂原脂多糖的反应正常。感染小鼠的肠系膜淋巴结细胞不会抑制正常肠系膜淋巴结细胞对绵羊红细胞的体外反应。这些结果表明，粗颈绦虫感染小鼠的免疫抑制主要是功能性辅助细胞改变的结果。
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