Doering G, Doering F, Podhaisky H, Hänsgen K, Preuss E G
Z Gesamte Inn Med. 1981 Oct 1;36(19):727-30.
For the purpose of testing extracardial haemodynamic effects of the calcium antagonist nifedipine (corinfar) in 15 patients with arterial obstructive disease and in a control group plethysmographic and doppler-sonographic measurements before and after oral application of the substance were performed. In these cases after the application of nifedipine a significant increase of the blood flow in the crural region developed. At the same time a slight decrease of the systolic pressure could be established at the upper and lower extremity. In patients with arterial obstructive disease these haemodynamic reactions had a less significant result. They correspond to an arterial vasodilatation with decrease of the peripheral resistance and simultaneously they explain a part of the antianginous effect of the calcium antagonist. The increase of the blood flow which is to be objectified after the application of nifedipine also in poststenotic areas might be of clinical importance particularly in the combined occurrence of atherosclerotically conditioned disturbances of the blood supply of the coronary and peripheral vascular system.
为测试钙拮抗剂硝苯地平（心痛定）对15例动脉阻塞性疾病患者的心外血流动力学影响，对一组对照组在口服该药物前后进行了体积描记法和多普勒超声测量。在这些病例中，应用硝苯地平后，下肢血流显著增加。同时，上肢和下肢的收缩压略有下降。在动脉阻塞性疾病患者中，这些血流动力学反应的结果不太显著。它们与动脉血管扩张及外周阻力降低相对应，同时也解释了钙拮抗剂的部分抗心绞痛作用。应用硝苯地平后在狭窄后区域也能证实的血流增加可能具有临床意义，尤其是在冠状动脉和外周血管系统因动脉粥样硬化导致供血障碍合并出现的情况下。
