Solomons N W, Elson C O, Pekarek R S, Jacob R A, Sandstead H H, Rosenberg I H
Infect Immun. 1978 Dec;22(3):637-9. doi: 10.1128/iai.22.3.637-639.1978.
Reduced concentrations of plasma zinc associated with elevated levels of serum leukocytic endogenous mediator activity were found in 17 patients hospitalized with acute exacerbation of Crohn's disease. Neither the decrease in plasma zinc nor the increase in leukocytic endogenous activator activity in nine outpatients with quiescent disease was significant. Leukocytic endogenous mediator activity may be increased in inflammatory conditions as well as in microbial infections. Although zinc deficiency may be common in patients with Crohn's disease, exclusive reliance on circulating zinc levels to assess zinc nutriture in active Crohn's disease may be misleading.
在17例因克罗恩病急性加重而住院的患者中，发现血浆锌浓度降低与血清白细胞内源性介质活性升高有关。9例病情静止的门诊患者，其血浆锌的降低及白细胞内源性激活剂活性的升高均不显著。白细胞内源性介质活性在炎症状态以及微生物感染时均可升高。虽然锌缺乏在克罗恩病患者中可能很常见，但在评估活动期克罗恩病患者的锌营养状况时，单纯依赖循环锌水平可能会产生误导。
