轻度克罗恩病患者体内硒浓度降低。
Reduced concentrations of selenium in mild Crohn's disease.
作者信息
Hinks L J, Inwards K D, Lloyd B, Clayton B
机构信息
Department of Chemical Pathology and Human Metabolism, Faculty of Medicine, University of Southampton, Southampton General Hospital.
出版信息
J Clin Pathol. 1988 Feb;41(2):198-201. doi: 10.1136/jcp.41.2.198.
The concentrations of selenium, zinc, and copper were determined in whole blood, plasma, and leucocytes in 20 patients with relatively mild Crohn's disease, nine of whom were being treated with steroids, and compared with those of a control group. There was a significant decrease in the concentration of selenium in the leucocytes as well as in whole blood and plasma in the patients. Steroids seemed to affect only the concentrations of zinc and copper in plasma. The concentrations of copper and zinc in whole blood, plasma, and leucocytes in patients not taking steroids were not significantly different from those of the control group. The observations suggest that those patients with an apparently satisfactory whole body concentration of copper and zinc may still be at risk of a decrease in the body content of selenium.
测定了20例病情相对较轻的克罗恩病患者全血、血浆和白细胞中硒、锌和铜的浓度，其中9例正在接受类固醇治疗，并与对照组进行了比较。患者白细胞以及全血和血浆中硒的浓度显著降低。类固醇似乎仅影响血浆中锌和铜的浓度。未服用类固醇的患者全血、血浆和白细胞中铜和锌的浓度与对照组无显著差异。这些观察结果表明，那些铜和锌全身浓度看似正常的患者仍可能存在体内硒含量降低的风险。
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