Rannikko S, Kairento A L, Karonen S L, Adlercreutz H
Acta Endocrinol (Copenh). 1981 Dec;98(4):625-33. doi: 10.1530/acta.0.0980625.
In 32 subjects with histologically and/or cytologically verified prostatic cancer the hormonal pattern was studied by assaying 18 plasma and urinary hormones or groups of hormones. The tumours were classified according to the UICC classification system and the hormone values were correlated to the local extent of the tumour (T classification), the presence of metastases (M classification) and the differentiation of grade (G classification). It was found that patients with metastases had significantly higher plasma oestradiol and lower testosterone/oestradiol and testosterone/oestrone plus oestradiol ratios as compared to those subjects without metastases. In subjects with moderately or poorly differentiated tumours plasma oestrone + oestradiol was significantly higher and the testosterone/oestrone + oestradiol ratio was significantly lower than in the subjects with well differentiated tumours. In the various TNM classification groups no obvious trends were found with regard to urinary hormones and no significant differences between the groups for plasma FSH, LH, prolactin, progesterone and cortisol were observed. It is concluded that in more advanced cases with metastatic cancer and when tumours are less well differentiated the androgen/oestrogen ratio may be decreased. These alterations have no diagnostic significance because of greater overlapping of individual results between the various groups of patients.
在32例经组织学和/或细胞学证实为前列腺癌的患者中，通过检测18种血浆和尿激素或激素组来研究激素模式。肿瘤根据国际抗癌联盟（UICC）分类系统进行分类，激素值与肿瘤的局部范围（T分类）、转移情况（M分类）和分级分化（G分类）相关。结果发现，与无转移的患者相比，有转移的患者血浆雌二醇显著升高，睾酮/雌二醇以及睾酮/雌酮加雌二醇的比值降低。与高分化肿瘤患者相比，中分化或低分化肿瘤患者血浆雌酮+雌二醇显著升高，睾酮/雌酮+雌二醇比值显著降低。在不同的TNM分类组中，未发现尿激素有明显趋势，且各组间血浆促卵泡生成素（FSH）、促黄体生成素（LH）、催乳素、孕酮和皮质醇未观察到显著差异。得出的结论是，在更晚期的转移性癌症病例以及肿瘤分化较差时，雄激素/雌激素比值可能降低。由于不同患者组个体结果的重叠性更大，这些改变没有诊断意义。
