Ridgway E C, Maloof F, Longcope C
J Endocrinol. 1982 Oct;95(1):105-15. doi: 10.1677/joe.0.0950105.
Using constant infusions of [3H]testosterone and [14C]oestradiol or [3H]androstenedione and [14C]oestrone the dynamics of androgen and oestrogen metabolism and production in patients with hyperthyroidism were measured. The metabolic clearance rates of testosterone and oestradiol were decreased but those of androstenedione and oestrone were within the normal range. The conversion ratios of testosterone to androstenedione and of testosterone to dihydrotestosterone (DHT) were decreased whereas those of androstenedione to testosterone and androstenedione to DHT were increased. These changes could be explained by increased serum levels of sex hormone binding globulin which binds testosterone and DHT but not androstenedione. The fraction of androstenedione infused into and measured as oestrone in the blood was normal in seven out of nine subjects and the fraction of testosterone infused and measured as oestradiol was normal in all nine subjects. The production rates of testosterone and oestradiol were in the normal range but the production rates of androstenedione and oestrone were raised in half the subjects.
通过持续输注[³H]睾酮和[¹⁴C]雌二醇或[³H]雄烯二酮和[¹⁴C]雌酮，测定了甲状腺功能亢进患者雄激素和雌激素代谢及生成的动态变化。睾酮和雌二醇的代谢清除率降低，但雄烯二酮和雌酮的代谢清除率在正常范围内。睾酮向雄烯二酮以及睾酮向双氢睾酮（DHT）的转化比率降低，而雄烯二酮向睾酮以及雄烯二酮向DHT的转化比率升高。这些变化可以通过血清性激素结合球蛋白水平升高来解释，该球蛋白可结合睾酮和DHT，但不结合雄烯二酮。在9名受试者中，有7名受试者输注的雄烯二酮在血液中转化为雌酮并测得的比例正常，而在所有9名受试者中，输注的睾酮转化为雌二醇并测得的比例均正常。睾酮和雌二醇的生成率在正常范围内，但一半受试者的雄烯二酮和雌酮生成率升高。
