Hidaka A, Shimazu T, Komatani M, Ikeda H, Sakamoto H, Sugawa T
Acta Obstet Gynaecol Jpn. 1981 Jul;33(7):925-34.
Placental and renal cortical blood flow were measured by thermocouple method in 70 cases of late pregnant rabbits, 17 late pregnant dogs and 2 late pregnant monkeys. Intrauterine resting tonus in 148 primigravid and 74 multigravid women tended to increase towards the onset of labor, with maternal mean blood pressure elevating in close relation to the intrauterine pressure. Especially in primigravid women there was a strong tendency and intrauterine resting tonus was higher value in primigravidas than that in multigravidas. The increasing of intrauterine pressure by uterine contraction caused an elevation of maternal blood pressure by about 10% in pregnant women, and caused a decrease of placental blood flow by about 30% respectively, but it did not show any definite pattern in renal cortical blood flow in experimental animals. On the other hand, the increasing of intrauterine resting tonus with intraamniotic saline injection in 47 cases of experimental animals brought about a decrease of placental blood flow by about 30%, at the same time caused a decrease of renal cortical blood flow by about 20% and an elevation of maternal blood pressure by about 10% respectively. These findings support the concept that increasing of uterine resting tonus could play a role in mediating late pregnancy induced hypertension.
采用热电偶法对70只妊娠晚期兔、17只妊娠晚期犬和2只妊娠晚期猴的胎盘和肾皮质血流量进行了测量。148例初产妇和74例经产妇的子宫内静息张力在临产时趋于升高，孕妇平均血压与子宫内压力密切相关而升高。尤其是初产妇有强烈的趋势，且初产妇的子宫内静息张力高于经产妇。子宫收缩引起的子宫内压力升高使孕妇的血压升高约10%，胎盘血流量分别减少约30%，但在实验动物中肾皮质血流量未显示出任何明确的变化规律。另一方面，47例实验动物经羊膜腔内注射生理盐水使子宫内静息张力升高，导致胎盘血流量减少约30%，同时肾皮质血流量减少约20%，孕妇血压升高约10%。这些发现支持了子宫静息张力增加可能在介导妊娠晚期高血压中起作用的观点。
