Punnonen R, Grönroos M, Meurman L, Liukko P
Acta Obstet Gynecol Scand. 1981;60(5):513-4. doi: 10.3109/00016348109155472.
Fifteen cases of primary carcinoma in situ or severe or moderate dysplasia of the vagina have been diagnosed and treated during the period 1966-75 at the Department of Obstetrics and Gynecology, Turku University Central Hospital. Because of abnormal vaginal cytology the lesion was localized by means of colposcopy and iodine staining. For 6 patients local estrogen treatment was applied to increase the thickness of the epidermal layer. For 6 patients, treatment consisted of simple excision. Nine patients, including both those with carcinoma in situ, were treated with intravaginal radiation therapy. The radiation dosage was 2 000 to 2 600 rad at a distance of 1 cm from the surface of the epithelium. None of the patients showed any complications, and all are now symptom-free.
1966年至1975年期间，图尔库大学中心医院妇产科诊断并治疗了15例原发性阴道原位癌或中重度发育异常。由于阴道细胞学检查异常，通过阴道镜检查和碘染色确定病变部位。对6例患者采用局部雌激素治疗以增加表皮层厚度。对6例患者采用单纯切除术治疗。9例患者，包括原位癌患者，接受了阴道内放射治疗。距上皮表面1厘米处的放射剂量为2000至2600拉德。所有患者均未出现任何并发症，目前均无症状。
