Leminen A, Forss M, Lehtovirta P
Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Finland.
Acta Obstet Gynecol Scand. 1995 May;74(5):379-83. doi: 10.3109/00016349509024433.
We analyzed 46 patients with primary carcinoma of the vagina treated between 1969 and 1990. Median age of the patients was 67 years (range 33-89 years). Most (52%) of them were obese and 35% were nulliparous. Four (9%) had suffered from other gynecologic carcinoma and had been operated six to 23 years before the current carcinoma. Forty (87%) patients had squamous cell carcinoma. Stage 0 (carcinoma in situ) was found in three (7%) cases and stage I-IV in 21 (54%), 10 (22%), four (9%) and eight (17%) cases, respectively. Most (81%) of the patients were treated with radiotherapy (alone or in combination with other treatments): combination of brachytherapy and external radiotherapy were used in 45% of the cases. Surgery was used in all stage 0 cases and in 52% of stage I cases. Recurrence of the disease was found in 20 (43%) cases during the follow-up of 10 years. Most often (40%) site of the recurrence was the vagina. Both 5- and 10-year survival were 38%. Stage and extent of the tumor were independent prognostic factors in stepwise multivariate analysis.
我们分析了1969年至1990年间接受治疗的46例原发性阴道癌患者。患者的中位年龄为67岁（范围33 - 89岁）。其中大多数（52%）为肥胖患者，35%未生育。4例（9%）曾患其他妇科癌症，在当前癌症发生前6至23年接受过手术。40例（87%）患者为鳞状细胞癌。0期（原位癌）3例（7%），Ⅰ - Ⅳ期分别为21例（54%）、10例（22%）、4例（9%）和8例（17%）。大多数（81%）患者接受了放射治疗（单独或与其他治疗联合）：45%的病例采用了近距离放疗和外照射放疗联合。所有0期病例及52%的Ⅰ期病例采用了手术治疗。在10年的随访期间，20例（43%）患者出现疾病复发。最常见的复发部位（40%）是阴道。5年和10年生存率均为38%。在逐步多因素分析中，肿瘤的分期和范围是独立的预后因素。
