Nakanishi I, Masuda S, Kitamura T, Moriizumi T, Kajikawa K
Acta Pathol Jpn. 1981 Sep;31(5):733-45. doi: 10.1111/j.1440-1827.1981.tb02799.x.
The occurrence and distribution of fibrous long-spacing fibers (FLS) of lymph nodes in normal and pathological conditions have been examined by electron microscopy. The FLS can be easily identified by the characteristic broad cross bands with a 90 to 120 nm period. In normal lymph nodes, the FLS were most often found in the stalk of the valve projecting into the lymphatic sinus and in the perivascular matrix, and less frequently in the wall of the vein, in the sinus wall and in the stroma of the medulla at the hilus. In pathological conditions, a large number of FLS appeared in the hyalinous matrix of lymphocyte depletion type of Hodgkin's disease. These fibers were also observed in reticular matrices of lymphosarcoma and mixed cellularity type of Hodgkin's disease as well as in granulation tissues. It was noted that FLS appeared to be formed in the regions where abundant reticular fibers were laid down. Compared with the ultrastructural and histological findings in various lesions of lymph nodes, the possible mechanism and significance of FLS were discussed.
通过电子显微镜检查了正常和病理条件下淋巴结中纤维性长间距纤维（FLS）的发生和分布情况。FLS可通过具有90至120nm周期的特征性宽交叉带轻松识别。在正常淋巴结中，FLS最常见于伸入淋巴窦的瓣膜柄和血管周围基质中，较少见于静脉壁、窦壁和门部髓质的基质中。在病理条件下，大量FLS出现在淋巴细胞耗竭型霍奇金病的透明基质中。在淋巴肉瘤的网状基质、混合细胞型霍奇金病以及肉芽组织中也观察到了这些纤维。值得注意的是，FLS似乎是在网状纤维丰富沉积的区域形成的。结合淋巴结各种病变的超微结构和组织学发现，对FLS的可能机制和意义进行了讨论。
