Möller P, Achtsätter H, Butzengeiger M, Schüle B
Virchows Arch A Pathol Anat Histopathol. 1983;400(3):319-29. doi: 10.1007/BF00612193.
The tissue distribution of fibronectin (FN) was examined using a commercial anti-FN serum, the peroxidase-anti-peroxidase (PaP) technique, and paraffin sections of 22 lymph nodes affected by Hodgkin's disease. Vascular basement membranes and reticulin fibres are selectively stained and their structural changes in this pathological condition become readily visible. In contrast to the normal lymph node and to Hodgkin's disease with lymphocytic predominance, cases of mixed cellularity disease contain individual and focally grouped cells displaying intracytoplasmic FN. In nodular sclerosis these cells with fibroblast morphology are consistently numerous in the marginal zones of the cellular nodes. Strongly reacting mastocytes probably absorbed the applied antiserum non-immunologically. All the other cell types giving rise to the varying appearances of Hodgkin's lesions are consistently negative with respect to intracellular FN, including all forms of Hodgkin cells. We conclude that in Hodgkin's disease the immigration of FN-secreting fibroblasts is an integral part of the early sclerosing reaction, which in itself is a defence/repair mechanism closely related to scar formation.
使用市售抗纤连蛋白（FN）血清、过氧化物酶-抗过氧化物酶（PaP）技术以及22例霍奇金病累及淋巴结的石蜡切片，对纤连蛋白（FN）的组织分布进行了检测。血管基底膜和网状纤维被选择性染色，并且在这种病理状态下它们的结构变化变得易于观察。与正常淋巴结以及淋巴细胞为主型霍奇金病不同，混合细胞型疾病的病例含有单个及局灶性聚集的细胞，这些细胞呈现胞质内FN。在结节硬化型中，具有成纤维细胞形态的这些细胞在细胞性结节的边缘区始终大量存在。强烈反应的肥大细胞可能非免疫性地吸收了所应用的抗血清。导致霍奇金病变呈现不同外观的所有其他细胞类型，包括所有形式的霍奇金细胞，细胞内FN始终为阴性。我们得出结论，在霍奇金病中，分泌FN的成纤维细胞的迁入是早期硬化反应的一个组成部分，而早期硬化反应本身是一种与瘢痕形成密切相关的防御/修复机制。
