Ishikawa E, Tanaka H, Kakimoto S, Takasaki S, Kirino Y, Sakata A, Suzuki M
Acta Pathol Jpn. 1981 Sep;31(5):767-81. doi: 10.1111/j.1440-1827.1981.tb02802.x.
The present study included 46 cases of eosinophilic lymphfolliculoid granuloma(kimura's disease), which occurred mainly in males between the ages of 11 to 52 years. The common sites were the soft tissue of the head and neck region. Although recurrence was not infrequent, the clinical course was benign. Laboratory findings revealed eosinophilia and frequent elevation of serum IgE. The histological characteristics consisted of proliferation of lymphoid follicles and granulation tissue with infiltration of eosinophils, mast cells, plasma cells, lymphocytes, and histiocytes, some degree of vascular proliferation, and fibrosis. With the appliance of unlabeled peroxidase-antiperoxidase method, a marked reticular reaction of IgE was confirmed in the germinal center of the folliculoid structure, and there were quite a number of IgE producing plasma cells. Many mast cells with IgE bound to their cell surface were seen in the granulation tissue. Toluidine blue staining and electron microscopy revealed fairly well preserved granules in mast cells, being quite different from the changes seen in type I allergy.
本研究纳入了46例嗜酸性淋巴滤泡样肉芽肿（木村病）患者，主要发生于11至52岁的男性。常见部位为头颈部软组织。尽管复发并不罕见，但临床病程为良性。实验室检查发现嗜酸性粒细胞增多以及血清IgE频繁升高。组织学特征包括淋巴滤泡和肉芽组织增生，伴有嗜酸性粒细胞、肥大细胞、浆细胞、淋巴细胞和组织细胞浸润，有一定程度的血管增生和纤维化。应用未标记过氧化物酶-抗过氧化物酶法，在滤泡样结构的生发中心证实有明显的IgE网状反应，并且有相当数量产生IgE的浆细胞。在肉芽组织中可见许多细胞表面结合有IgE的肥大细胞。甲苯胺蓝染色和电子显微镜检查显示肥大细胞内颗粒保存相当完好，这与I型过敏所见的变化截然不同。
