Ambler M W, Neave C, Sturner W Q
Am J Forensic Med Pathol. 1981 Mar;2(1):23-30. doi: 10.1097/00000433-198103000-00005.
This report describes the neuropathological findings in 58 infants and children dying suddenly and unexpectedly. Utilizing historical, clinical, laboratory and pathological findings, two subgroups were distinguished: in one a cause of death was established (CODE); members of the other (more than 50% of the total sample) were victims of sudden infant death syndrome (SIDS). The importance of historical as well as pathological data in excluding SIDS is stressed. In each subgroup, both focal lesions and diffuse glial reactive hypertrophy were identified in 64% of all children below 9 months of age. These changes were not related to age group or maturation and, except for a history of perinatal asphyxia, lesions were not predictably correlated with clinical data. The brains of children dying of established cause (CODE) are not a suitable control group with which to compare those of SIDS.
本报告描述了58例突然意外死亡的婴儿和儿童的神经病理学发现。利用病史、临床、实验室和病理学发现，区分出两个亚组：一组确定了死因（CODE）；另一组（占总样本的50%以上）是婴儿猝死综合征（SIDS）的受害者。强调了病史以及病理数据在排除SIDS方面的重要性。在每个亚组中，所有9个月以下儿童中有64%发现了局灶性病变和弥漫性胶质细胞反应性肥大。这些变化与年龄组或成熟度无关，除了围产期窒息史外，病变与临床数据没有可预测的相关性。死于已确定病因（CODE）的儿童的大脑不是与SIDS儿童大脑进行比较的合适对照组。
