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自身免疫性血小板减少症中的补体结合血小板自身抗体

Complement-fixing platelet autoantibodies in autoimmune thrombocytopenia.

作者信息

Kayser W, Meuller-Eckhardt C, Budde U, Schmidt R E

出版信息

Am J Hematol. 1981 Sep;11(2):213-9. doi: 10.1002/ajh.2830110213.

DOI:10.1002/ajh.2830110213
PMID:7304609
Abstract

A 16-year-old male patient is described with chronic autoimmune thrombocytopenic purpura and, after two years, "warm" autoimmune hemolytic anemia (Evans syndrome) who transiently developed complement-fixing platelet autoantibodies. The autoreactivity of these antibodies was established by quantitative complement fixation as well as by absorption and elution studies using autologous platelets. We believe this to be the first documented case with this very rare and peculiar type of platelet autoantibody.

摘要

本文描述了一名16岁男性患者,患有慢性自身免疫性血小板减少性紫癜,两年后又出现“温抗体型”自身免疫性溶血性贫血(伊文氏综合征),该患者短暂产生了补体结合性血小板自身抗体。这些抗体的自身反应性通过定量补体结合试验以及使用自体血小板的吸收和洗脱研究得以确定。我们认为这是首例记录在案的这种极为罕见且特殊类型的血小板自身抗体病例。

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引用本文的文献

1
Possible mechanisms of intravenous immunoglobulin treatment in childhood idiopathic thrombocytopenic purpura (ITP).静脉注射免疫球蛋白治疗儿童特发性血小板减少性紫癜(ITP)的可能机制。
Blut. 1983 Mar;46(3):117-24. doi: 10.1007/BF00320269.
2
Specific and nonspecific mechanisms of action of immunoglobulin G in therapy of idiopathic thrombocytopenic purpura (ITP).免疫球蛋白G在特发性血小板减少性紫癜(ITP)治疗中的特异性和非特异性作用机制。
Blut. 1984 Jun;48(6):345-51. doi: 10.1007/BF00319961.
3
The role of complement in immune clearance of blood cells.
补体在血细胞免疫清除中的作用。
Springer Semin Immunopathol. 1983;6(4):373-98. doi: 10.1007/BF02116281.
4
In vitro fixation of C3d and C5b-9 on platelets by human platelet reactive antibodies.人血小板反应性抗体对血小板上C3d和C5b-9的体外固定作用。
Blut. 1989 Jan;58(1):33-7. doi: 10.1007/BF00320233.
5
Recent trends in platelet antigen/antibody detection.血小板抗原/抗体检测的最新趋势
Blut. 1989 Jul;59(1):35-43. doi: 10.1007/BF00320246.