Kagan R J, Glassford G H
Am Surg. 1981 Nov;47(11):509-10.
A case of coumadin necrosis of the breast is presented. Most patients with this entity are obese, middle-aged females who have been treated with oral anticoagulants for three to five days for thrombophlebitis or peripheral arterial embolization. The key to therapy is early diagnosis and clinical differentiation from subcutaneous hemorrhage--a disease which is self-limited, nonprogressive, and treatable when anticoagulant therapy is either discontinued or reversed with vitamin K. Surgical debridement or simple mastectomy is generally necessary in those cases where necrosis is present.
本文报告一例乳房华法林坏死病例。患有此病症的大多数患者为肥胖的中年女性，她们因血栓性静脉炎或外周动脉栓塞接受了三至五天的口服抗凝剂治疗。治疗的关键在于早期诊断以及与皮下出血进行临床鉴别——皮下出血是一种自限性、非进行性疾病，在停用抗凝剂或用维生素K逆转抗凝治疗后可治愈。对于出现坏死的病例，通常需要进行手术清创或单纯乳房切除术。
