Polosova R G, Balashev V N
Antibiotiki. 1981 Oct;26(10):756-61.
The effect of mannan, a polysaccharide of the microbial origin on the content of protein fractions, total protein, glucose, cholesterol (total, free and bound), urea, urea nitrogen and residual nitrogen in the lymph and serum of blood was studied on rabbits. Mannan was administered intramuscularly in the form of a 0.06 per cent solution in single doses of 0.06-6 mg/kg and repeatedly in doses of 0.60-3 mg/kg for 3-49 days. The lymph specimens were collected from the thoracic duct 1 and 24 hours after mannan administration. The study showed that in any dose administered once mannan induced an increase in the content of upsilon-globulin in the lymph and no increase in the blood serum, characterized by changes in the ratio of the other protein fractions. No other changes in the biochemical indices of the blood lymph and serum in the experimental animals were noted. When used repeatedly mannan had no effect on the content of protein fractions in the blood lymph and serum. the study on changes in the biochemical indices of the lymph provided additional data on the character of the mannan effect in the host.
研究了微生物来源的多糖甘露聚糖对家兔淋巴液和血清中蛋白质组分、总蛋白、葡萄糖、胆固醇（总胆固醇、游离胆固醇和结合胆固醇）、尿素、尿素氮和残余氮含量的影响。甘露聚糖以0.06%溶液的形式肌肉注射，单次剂量为0.06 - 6mg/kg，重复剂量为0.60 - 3mg/kg，持续3 - 49天。在注射甘露聚糖后1小时和24小时从胸导管采集淋巴液样本。研究表明，单次给予任何剂量的甘露聚糖都会导致淋巴液中γ-球蛋白含量增加，而血清中无增加，其特征是其他蛋白质组分的比例发生变化。实验动物的血液、淋巴液和血清的其他生化指标未出现其他变化。当重复使用甘露聚糖时，对血液、淋巴液和血清中蛋白质组分的含量没有影响。对淋巴液生化指标变化的研究为甘露聚糖在宿主体内的作用特性提供了更多数据。
