Schouten J T, Weese J L, Carbone P P
Ann Surg. 1981 Dec;194(6):749-53. doi: 10.1097/00000658-198112000-00015.
Thirteen patients with lymphoma of the breast are presented. In addition, 163 previously reported cases of lymphoma of the breast are reviewed. Complete staging was performed on all patients. No patient had a diagnosis of lymphoma prior to breast biopsy. The histologic findings were diffuse histiocytic lymphoma (DHL) in eight patients, nodular lymphocytic poorly differentiated lymphoma (NLPD) in two patients, nodular mixed lymphoma (NM) in two patients and nodular sclerosing Hodgkin's disease (NSHD) in one patient. Five patients had Stage IV disease, two had Stage III disease, four had stage II disease and two Stage I disease. Nine patients each underwent an excisional biopsy and four patients each had a modified radical mastectomy as initial therapy. Two patients each underwent a staging laparotomy. In advanced disease, chemotherapy achieved complete remissions in approximately 50% of patients. Unfavorable histologic findings are most common in lymphoma of the breast and thorough staging is necessary to select the best form of therapy. The absolute survival rate (61%) and the disease free survival rate (46%) are similar to nodal lymphoma of corresponding histologic factors and stage.
本文报告了13例乳腺淋巴瘤患者。此外，还回顾了之前报道的163例乳腺淋巴瘤病例。对所有患者进行了全面分期。在乳腺活检之前，没有患者被诊断为淋巴瘤。组织学检查结果显示，8例为弥漫性组织细胞淋巴瘤（DHL），2例为结节性淋巴细胞低分化淋巴瘤（NLPD），2例为结节性混合淋巴瘤（NM），1例为结节硬化型霍奇金病（NSHD）。5例患者为IV期疾病，2例为III期疾病，4例为II期疾病，2例为I期疾病。9例患者分别接受了切除活检，4例患者分别接受了改良根治性乳房切除术作为初始治疗。2例患者分别接受了分期剖腹探查术。在晚期疾病中，化疗使约50%的患者实现了完全缓解。不良组织学表现在乳腺淋巴瘤中最为常见，全面分期对于选择最佳治疗方式很有必要。绝对生存率（61%）和无病生存率（46%）与具有相应组织学因素和分期的淋巴结淋巴瘤相似。
