Wallace D J, Goldfinger D, Klinenberg J R
Artif Organs. 1981 Aug;5(3):297-8. doi: 10.1111/j.1525-1594.1981.tb04005.x.
Evidence developed over the years has suggested that lymphocyte depletion and removal of plasma factors can ameliorate rheumatoid arthritis. In our studies of 40 patients, a subset of patients that respond best to 20 therapeutic lymphoplasmapheresis over 11 weeks has emerged. These are functional Class III patients with seropositive, erosive progressive disease who have little deformity. They must be on long-acting agents or cytotoxic drugs during pheresis to prevent antibody rebound. Other studies have since confirmed our work. The major side effects of pheresis are elucidated. Technologic developments will enable selective pheresis procedures to be in widespread use within a few years.
多年来积累的证据表明，淋巴细胞清除和血浆因子去除可改善类风湿性关节炎。在我们对40名患者的研究中，出现了一组对11周内进行的20次治疗性淋巴细胞去除术反应最佳的患者。这些是功能性III类患者，患有血清阳性、侵蚀性进展性疾病，几乎没有畸形。在进行去除术期间，他们必须使用长效药物或细胞毒性药物以防止抗体反弹。此后其他研究证实了我们的工作。阐明了去除术的主要副作用。技术发展将使选择性去除术在几年内得到广泛应用。
