完整及脾切除的奔跑和游泳比格犬的血浆肾素活性和血浆儿茶酚胺

Plasma renin activity and plasma catecholamines in intact and splenectomized running and swimming beagle dogs.

作者信息

Joles J A, den Hertog J M, Huisman G H, Kraan W J, van Schaik F W, Schrikker A C

出版信息

Eur J Appl Physiol Occup Physiol. 1982;49(1):111-9. doi: 10.1007/BF00428969.

Abstract

The influence of splenectomy in the dog on plasma catecholamine levels and plasma renin activity during treadmill running and swimming was investigated. Plasma catecholamines were measured by a radioenzymatic assay and plasma renin activity by a radioimmunoassay. Exercise consistently increased plasma catecholamine levels before and after splenectomy (range of increase:3--38 pmol X ml-1). Swimming, however, was a stronger stimulus than running. No change in the ratio between noradrenaline and adrenaline was found. In intact dogs exercise results in a marked increase in hematocrit due to splenic contraction (range of increase 3--8 volume %), while renal blood flow and plasma renin activity remain virtually constant. In splenectomized dogs, exercise has been reported to induce a decrease in renal blood flow. In contrast to this known effect on renal blood flow, splenectomy did not affect plasma renin activity in treadmill running dogs. In swimming dogs, however, plasma renin activity was increased after splenectomy (range of increase 3.3--6.9 ng X Ang I X ml-1 X h-1). Possibly, a threshold in sympathetic tone is required to increase renin release in the dog.

摘要

研究了犬脾切除对跑步机跑步和游泳期间血浆儿茶酚胺水平及血浆肾素活性的影响。血浆儿茶酚胺采用放射酶法测定，血浆肾素活性采用放射免疫法测定。脾切除前后，运动均持续增加血浆儿茶酚胺水平（增加范围：3 - 38 pmol×ml⁻¹）。然而，游泳比跑步是更强的刺激因素。去甲肾上腺素与肾上腺素的比例未发现变化。在完整犬中，运动因脾脏收缩导致血细胞比容显著增加（增加范围3 - 8体积%），而肾血流量和血浆肾素活性基本保持不变。据报道，在脾切除犬中，运动可导致肾血流量减少。与这种对肾血流量的已知影响相反，脾切除对跑步机跑步的犬的血浆肾素活性没有影响。然而，在游泳的犬中，脾切除后血浆肾素活性增加（增加范围3.3 - 6.9 ng×血管紧张素I×ml⁻¹×h⁻¹）。可能，犬体内增加肾素释放需要交感神经张力达到一定阈值。