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人尿中的异锁链素。早期发育阶段及马方综合征患者体内的含量。

Desmosines in human urine. Amounts in early development and in Marfan's syndrome.

作者信息

Gunja-Smith Z, Boucek R J

出版信息

Biochem J. 1981 Mar 1;193(3):915-8. doi: 10.1042/bj1930915.

DOI:10.1042/bj1930915
PMID:7305966
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1162685/
Abstract

Desmosines from 24 h human urine samples were isolated, characterized and quantified. The desmosines are in peptidyl form (1000--1500 molecular weight), and their amount is decreased by two-thirds between 7 and 25 years of age. Patients with Marfan's syndrome have significantly lower urinary amounts of desmosines than do comparable controls during the early development period.

摘要

从24小时的人类尿液样本中分离、鉴定并定量了异锁链素。异锁链素呈肽基形式（分子量为1000 - 1500），其含量在7至25岁之间减少了三分之二。在早期发育阶段，马凡氏综合征患者尿液中的异锁链素含量显著低于相应的对照组。

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Biochem J. 1981 Mar 1;193(3):915-8. doi: 10.1042/bj1930915.
2
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引用本文的文献

1
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Proc Natl Acad Sci U S A. 2003 Oct 28;100(22):12941-3. doi: 10.1073/pnas.2235344100. Epub 2003 Oct 16.
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3
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J Clin Invest. 1982 Dec;70(6):1245-52. doi: 10.1172/jci110723.
4
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Marked longevity of human lung parenchymal elastic fibers deduced from prevalence of D-aspartate and nuclear weapons-related radiocarbon.从D-天冬氨酸的普遍存在及与核武器相关的放射性碳推断出人类肺实质弹性纤维显著的长寿特性。
J Clin Invest. 1991 May;87(5):1828-34. doi: 10.1172/JCI115204.

本文引用的文献

1
Histology of the Coronary Arteries and their Branches in the Human Heart.人类心脏冠状动脉及其分支的组织学
Am J Pathol. 1934 Mar;10(2):253-274.7.
2
PARTIAL STRUCTURE OF TWO MAJOR DEGRADATION PRODUCTS FROM THE CROSS-LINKAGES IN ELASTIN.弹性蛋白中交联键产生的两种主要降解产物的部分结构
Nature. 1963 Nov 16;200:651-2. doi: 10.1038/200651a0.
3
The pathogenesis of atheroma of the coronary arteries.冠状动脉粥样硬化的发病机制。
J Pathol Bacteriol. 1956 Jul;72(1):83-6. doi: 10.1002/path.1700720111.
4
X-linked cutis laxa: defective cross-link formation in collagen due to decreased lysyl oxidase activity.X连锁隐性遗传性皮肤松弛症：由于赖氨酰氧化酶活性降低，胶原蛋白中交联形成存在缺陷。
N Engl J Med. 1980 Jul 10;303(2):61-5. doi: 10.1056/NEJM198007103030201.
5
The isolation of identical hydroxylysyl glycosides from hydrolysates of soluble collagen and from human urine.从可溶性胶原蛋白水解产物和人尿中分离出相同的羟赖氨酰糖苷。
J Biol Chem. 1967 May 25;242(10):2570-1.
6
The biosynthesis of desmosine and isodesmosine.锁链素和异锁链素的生物合成。
J Biol Chem. 1966 Oct 25;241(20):4638-41.
7
Urinary peptides derived from the cross-linked regions of connective tissue proteins.源自结缔组织蛋白交联区域的尿肽。
Nature. 1968 Feb 17;217(5129):661. doi: 10.1038/217661a0.
8
Pathogenesis of primary abnormalities of the mitral valve in Marfan's syndrome.马方综合征二尖瓣原发性异常的发病机制。
Br Heart J. 1969 Nov;31(6):679-83. doi: 10.1136/hrt.31.6.679.
9
The growth and development of the rat aorta. II. Changes in nucleic acid and scleroprotein content.大鼠主动脉的生长与发育。II. 核酸和硬蛋白含量的变化。
J Anat. 1972 Oct;113(Pt 1):17-34.
10
The production of lysyl oxidase by human fibroblasts in culture.
Arch Biochem Biophys. 1972 Mar;149(1):97-101. doi: 10.1016/0003-9861(72)90302-5.