Drazen J M, Loring S H, Venugopalan C
J Appl Physiol Respir Environ Exerc Physiol. 1978 Dec;45(6):957-61. doi: 10.1152/jappl.1978.45.6.957.
The effects of intravenous antigen infusion on lung volumes and quasi-static deflationary pulmonary compliance in guinea pigs previously sensitized to ovalbumin were studied in vivo. Ovalbumin infusion significantly increased minimal gas volume to a similar extent in animals with intact or cut vagi. Total lung capacity fell only in animals with intact vagi. Quasi-static compliance fell in both groups of animals, but the fall was significantly greater in animals with intact vagi. These data demonstrate that immediate hypersensitivity reactions alter lung volumes and the elastic properties of the lung by both vagal dependent and vagal independent mechanisms.
在体内研究了静脉注射抗原对先前已对卵清蛋白致敏的豚鼠肺容量和准静态肺萎陷顺应性的影响。在迷走神经完整或切断的动物中，注射卵清蛋白均能使最小气体量显著增加，且增加程度相似。仅在迷走神经完整的动物中，肺总量下降。两组动物的准静态顺应性均下降，但迷走神经完整的动物下降幅度显著更大。这些数据表明，速发型超敏反应通过迷走神经依赖性和非依赖性机制改变肺容量和肺的弹性特性。
