肾上腺素及其他变力性药物对灌注大鼠心脏中丙酮酸脱氢酶的激活作用。
The activation of pyruvate dehydrogenase in the perfused rat heart by adrenaline and other inotropic agents.
作者信息
McCormack J G, Denton R M
出版信息
Biochem J. 1981 Feb 15;194(2):639-43. doi: 10.1042/bj1940639.
Abstract
Adrenaline resulted in a reversible 4-fold increase in the amount of pyruvate dehydrogenase in its active non-phosphorylated form in the perfused rat heart within 1 min. The increase was less in extent in hearts from starved or diabetic rats or in hearts from control rats oxidizing acetate, unless pyruvate was added to the perfusion medium. Increases could also be induced by other inotropic agents, supporting the hypothesis that increases in cytoplasmic Ca2+ can be relayed into mitochondria and influence oxidative metabolism.
摘要
肾上腺素可使灌注的大鼠心脏中处于活性非磷酸化形式的丙酮酸脱氢酶量在1分钟内可逆性增加4倍。在饥饿或糖尿病大鼠的心脏中，或在氧化乙酸盐的对照大鼠心脏中，这种增加的程度较小，除非向灌注培养基中添加丙酮酸。其他变力性药物也可诱导增加，这支持了细胞质Ca2+的增加可传递到线粒体并影响氧化代谢的假说。
相似文献
1
The activation of pyruvate dehydrogenase in the perfused rat heart by adrenaline and other inotropic agents.肾上腺素及其他变力性药物对灌注大鼠心脏中丙酮酸脱氢酶的激活作用。
Biochem J. 1981 Feb 15;194(2):639-43. doi: 10.1042/bj1940639.
2
Ruthenium Red inhibits the activation of pyruvate dehydrogenase caused by positive inotropic agents in the perfused rat heart.钌红抑制灌注大鼠心脏中由正性肌力药物引起的丙酮酸脱氢酶的激活。
Biochem J. 1983 Aug 15;214(2):581-5. doi: 10.1042/bj2140581.
3
Studies on the interactions of Ca2+ and pyruvate in the regulation of rat heart pyruvate dehydrogenase activity. Effects of starvation and diabetes.关于Ca2+与丙酮酸在调节大鼠心脏丙酮酸脱氢酶活性中的相互作用的研究。饥饿和糖尿病的影响。
Biochem J. 1982 Feb 15;202(2):419-27. doi: 10.1042/bj2020419.
4
Regulation of pyruvate dehydrogenase in rat heart. Mechanism of regulation of proportions of dephosphorylated and phosphorylated enzyme by oxidation of fatty acids and ketone bodies and of effects of diabetes: role of coenzyme A, acetyl-coenzyme A and reduced and oxidized nicotinamide-adenine dinucleotide.大鼠心脏中丙酮酸脱氢酶的调节。脂肪酸和酮体氧化对去磷酸化和磷酸化酶比例的调节机制以及糖尿病的影响：辅酶A、乙酰辅酶A以及还原型和氧化型烟酰胺腺嘌呤二核苷酸的作用
Biochem J. 1976 Feb 15;154(2):327-48. doi: 10.1042/bj1540327.
5
Role of Ca2+ ions in the regulation of intramitochondrial metabolism in rat heart. Evidence from studies with isolated mitochondria that adrenaline activates the pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase complexes by increasing the intramitochondrial concentration of Ca2+.钙离子在大鼠心脏线粒体内代谢调节中的作用。来自对分离线粒体研究的证据表明，肾上腺素通过增加线粒体内钙离子浓度来激活丙酮酸脱氢酶和2-氧代戊二酸脱氢酶复合物。
Biochem J. 1984 Feb 15;218(1):235-47. doi: 10.1042/bj2180235.
6
Conversion of inactive (phosphorylated) pyruvate dehydrogenase complex into active complex by the phosphate reaction in heart mitochondria is inhibited by alloxan-diabetes or starvation in the rat.大鼠体内的四氧嘧啶糖尿病或饥饿会抑制心脏线粒体中通过磷酸反应将无活性（磷酸化）丙酮酸脱氢酶复合体转化为活性复合体的过程。
Biochem J. 1978 Aug 1;173(2):669-680. doi: 10.1042/bj1730669.
7
Studies on the activation of rat liver pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase by adrenaline and glucagon. Role of increases in intramitochondrial Ca2+ concentration.肾上腺素和胰高血糖素对大鼠肝脏丙酮酸脱氢酶和2-氧代戊二酸脱氢酶的激活作用研究。线粒体内钙离子浓度升高的作用。
Biochem J. 1985 Nov 1;231(3):597-608. doi: 10.1042/bj2310597.
8
Effect of the fatty acid oxidation inhibitor 2-tetradecylglycidic acid on pyruvate dehydrogenase complex activity in starved and alloxan-diabetic rats.脂肪酸氧化抑制剂2-十四烷基缩水甘油酸对饥饿和四氧嘧啶糖尿病大鼠丙酮酸脱氢酶复合体活性的影响。
Biochem J. 1982 Oct 15;208(1):53-60. doi: 10.1042/bj2080053.
9
Studies of the effects of beta-adrenergic agonists on the regulation of pyruvate dehydrogenase in the perfused rat heart.β-肾上腺素能激动剂对灌注大鼠心脏丙酮酸脱氢酶调节作用的研究。
J Biol Chem. 1980 Aug 25;255(16):7604-9.
10
Acute regulation of the branched-chain 2-oxo acid dehydrogenase complex by adrenaline and glucagon in the perfused rat heart.肾上腺素和胰高血糖素对灌注大鼠心脏中支链2-氧代酸脱氢酶复合体的急性调节作用
Biochem J. 1988 Mar 15;250(3):835-41. doi: 10.1042/bj2500835.
引用本文的文献
1
Glucagon and Its Receptors in the Mammalian Heart.哺乳动物心脏中的胰高血糖素及其受体。
Int J Mol Sci. 2023 Aug 15;24(16):12829. doi: 10.3390/ijms241612829.
2
Nutrient sensing and utilization: Getting to the heart of metabolic flexibility.营养感知与利用：探寻代谢灵活性的核心
Biochimie. 2016 May;124:74-83. doi: 10.1016/j.biochi.2015.10.013. Epub 2015 Oct 22.
3
Cardiac mitochondrial matrix and respiratory complex protein phosphorylation.心脏线粒体基质和呼吸复合物蛋白磷酸化。
Am J Physiol Heart Circ Physiol. 2012 Oct 15;303(8):H940-66. doi: 10.1152/ajpheart.00077.2012. Epub 2012 Aug 10.
4
Mitochondrial Ca²⁺ homeostasis: mechanism, role, and tissue specificities.线粒体钙离子稳态：机制、作用和组织特异性。
Pflugers Arch. 2012 Jul;464(1):3-17. doi: 10.1007/s00424-012-1122-y. Epub 2012 Jun 16.
5
Role of mitochondrial Ca2+ in the regulation of cellular energetics.线粒体钙在细胞能量调节中的作用。
Biochemistry. 2012 Apr 10;51(14):2959-73. doi: 10.1021/bi2018909. Epub 2012 Mar 29.
6
Adrenaline increases skeletal muscle glycogenolysis, pyruvate dehydrogenase activation and carbohydrate oxidation during moderate exercise in humans.在人体进行适度运动期间，肾上腺素会增加骨骼肌糖原分解、丙酮酸脱氢酶激活及碳水化合物氧化。
J Physiol. 2001 Jul 1;534(Pt 1):269-78. doi: 10.1111/j.1469-7793.2001.t01-1-00269.x.
7
The alpha-adrenergic-mediated activation of Ca2+ influx into cardiac mitochondria. A possible mechanism for the regulation of intramitochondrial free CA2+.α-肾上腺素能介导的Ca2+流入心脏线粒体的激活。一种调节线粒体内游离Ca2+的可能机制。
Biochem J. 1981 Nov 15;200(2):379-88. doi: 10.1042/bj2000379.
8
Evidence for the existence of regulatory sites for Ca2+ on the Na+/Ca2+ carrier of cardiac mitochondria.心脏线粒体Na+/Ca2+载体上存在Ca2+调节位点的证据。
Biochem J. 1982 Feb 15;202(2):509-18. doi: 10.1042/bj2020509.
9
The alpha-adrenergic-mediated activation of the cardiac mitochondrial Ca2+ uniporter and its role in the control of intramitochondrial Ca2+ in vivo.α-肾上腺素能介导的心脏线粒体钙离子单向转运体的激活及其在体内线粒体钙调控中的作用。
Biochem J. 1983 Nov 15;216(2):333-42. doi: 10.1042/bj2160333.
10
Role of Ca2+ ions in the regulation of intramitochondrial metabolism in rat heart. Evidence from studies with isolated mitochondria that adrenaline activates the pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase complexes by increasing the intramitochondrial concentration of Ca2+.钙离子在大鼠心脏线粒体内代谢调节中的作用。来自对分离线粒体研究的证据表明，肾上腺素通过增加线粒体内钙离子浓度来激活丙酮酸脱氢酶和2-氧代戊二酸脱氢酶复合物。
Biochem J. 1984 Feb 15;218(1):235-47. doi: 10.1042/bj2180235.
本文引用的文献
1
2
Studies on the incorporation of [32P]phosphate into pyruvate dehydrogenase in intact rat fat-cells. Effects of insulin.关于[32P]磷酸盐掺入完整大鼠脂肪细胞中丙酮酸脱氢酶的研究。胰岛素的作用。
Biochem J. 1980 Nov 15;192(2):469-81. doi: 10.1042/bj1920469.
3
On the role of the calcium transport cycle in heart and other mammalian mitochondria.论钙转运循环在心脏及其他哺乳动物线粒体中的作用。
FEBS Lett. 1980 Sep 22;119(1):1-8. doi: 10.1016/0014-5793(80)80986-0.
4
Role of calcium ions in the regulation of intramitochondrial metabolism. Effects of Na+, Mg2+ and ruthenium red on the Ca2+-stimulated oxidation of oxoglutarate and on pyruvate dehydrogenase activity in intact rat heart mitochondria.钙离子在调节线粒体内代谢中的作用。钠离子、镁离子和钌红对完整大鼠心脏线粒体中钙离子刺激的草酰戊二酸氧化及丙酮酸脱氢酶活性的影响。
Biochem J. 1980 Jul 15;190(1):107-17. doi: 10.1042/bj1900107.
5
Studies of the effects of beta-adrenergic agonists on the regulation of pyruvate dehydrogenase in the perfused rat heart.β-肾上腺素能激动剂对灌注大鼠心脏丙酮酸脱氢酶调节作用的研究。
J Biol Chem. 1980 Aug 25;255(16):7604-9.
6
Metabolic effects of epinephrine in the perfused rat heart. II. Control steps of glucose and glycogen metabolism.肾上腺素对灌注大鼠心脏的代谢作用。II. 葡萄糖和糖原代谢的调控步骤。
Mol Pharmacol. 1966 May;2(3):206-20.
7
8
Mechanisms regulating adipose-tissue pyruvate dehydrogenase.调节脂肪组织丙酮酸脱氢酶的机制
Biochem J. 1972 Sep;129(3):763-73. doi: 10.1042/bj1290763.
9
Mechanism of activation of pyruvate dehydrogenase by dichloroacetate and other halogenated carboxylic acids.二氯乙酸及其他卤代羧酸激活丙酮酸脱氢酶的机制。
Biochem J. 1974 Sep;141(3):761-74. doi: 10.1042/bj1410761.
10
Effect of glucagon on cyclic 3',5'-AMP, phosphorylase activity and contractility of heart muscle of the rat.胰高血糖素对大鼠心肌环3',5'-磷酸腺苷、磷酸化酶活性及收缩性的影响。
Circ Res. 1970 Feb;26(2):225-33. doi: 10.1161/01.res.26.2.225.
Zotero 插件