Miller W C, Rice D L, Kreusel R G, Bedrossian C W
J Appl Physiol Respir Environ Exerc Physiol. 1978 Dec;45(6):962-5. doi: 10.1152/jappl.1978.45.6.962.
Monocrotaline, a plant alkaloid shown histologically to produce pulmonary endothelial damage and edema, was used in dogs to produce an acute model of noncardiogenic pulmonary edema. Following intravenous injection there was no change in pulmonary vascular pressures or heart rate; cardiac output fell and pulmonary vascular resistance increased. After 2 h measurement of lung water demonstrated modest pulmonary edema in all animals. The degree of edema produced was more consistent and reproducible than that following alloxan or alpha-naphthylthiourea.
野百合碱是一种经组织学证明可导致肺内皮损伤和水肿的植物生物碱，曾被用于犬类以建立非心源性肺水肿的急性模型。静脉注射后，肺血管压力和心率无变化；心输出量下降，肺血管阻力增加。2小时后对肺水的测量显示，所有动物均出现轻度肺水肿。与使用四氧嘧啶或α-萘基硫脲后相比，所产生的水肿程度更一致且可重复。
