类视黄醇和佛波酯对不同细胞系对多肽毒素相思豆毒素、红豆毒素、蓖麻毒素和白喉毒素敏感性的影响。
Effects of retinoids and phorbol esters on the sensitivity of different cell lines to the polypeptide toxins modeccin, abrin, ricin and diphtheria toxin.
作者信息
Sandvig K, Olsnes S
出版信息
Biochem J. 1981 Mar 15;194(3):821-7. doi: 10.1042/bj1940821.
Abstract
The effects of retinoic acid and 12-O-tetradecanoylphorbol 13-acetate on the sensitivities of a number of cell lines to the toxins modeccin, abrin, ricin and diphtheria toxin were studied. Retinoic acid and some other retinoids were found to protect a number of the cell lines against the toxins. HeLa cells that were protected bound much more retinoic acid than L-cells that were not protected. The tumour promoter 12-O-tetradecanoylphorbol 13-acetate was found to increase the sensitivity of cells to abrin, ricin and modeccin in the absence as well as in the presence of retinoic acid. Neither retinoic acid nor 12-O-tetradecanoylphorbol 13-acetate affected the extent of binding and pinocytotic uptake of toxins by the cells. Apparently retinoic acid and 12-O-tetradecanoylphorbol 13-acetate interfere with the entry of the toxins through the cell membrane.
摘要
研究了视黄酸和12 - O - 十四烷酰佛波醇 - 13 - 乙酸酯对多种细胞系对毒素相思豆毒素、蓖麻毒素和白喉毒素敏感性的影响。发现视黄酸和其他一些类视黄醇可保护多种细胞系免受毒素侵害。受到保护的HeLa细胞比未受保护的L - 细胞结合更多的视黄酸。发现肿瘤促进剂12 - O - 十四烷酰佛波醇 - 13 - 乙酸酯在有无视黄酸的情况下均会增加细胞对相思豆毒素、蓖麻毒素和相思子毒素的敏感性。视黄酸和12 - O - 十四烷酰佛波醇 - 13 - 乙酸酯均不影响细胞对毒素的结合程度和胞饮摄取。显然，视黄酸和12 - O - 十四烷酰佛波醇 - 13 - 乙酸酯会干扰毒素通过细胞膜的进入。
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Effects of retinoids and phorbol esters on the sensitivity of different cell lines to the polypeptide toxins modeccin, abrin, ricin and diphtheria toxin.类视黄醇和佛波酯对不同细胞系对多肽毒素相思豆毒素、红豆毒素、蓖麻毒素和白喉毒素敏感性的影响。
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本文引用的文献
1
Biologically active phorbol esters specifically alter affinity of epidermal growth factor membrane receptors.生物活性佛波醇酯特异性改变表皮生长因子膜受体的亲和力。
Nature. 1979 May 31;279(5712):387-91. doi: 10.1038/279387a0.
2
A human melanoma cell line established from xenograft in athymic mice.一种从无胸腺小鼠异种移植瘤中建立的人黑色素瘤细胞系。
Br J Cancer. 1980 May;41(5):724-33. doi: 10.1038/bjc.1980.134.
3
Rapid alteration in Ca++ content and fluxes in phorbol 12-myristate 13-acetate treated myoblasts.佛波醇12-肉豆蔻酸酯13-乙酸酯处理的成肌细胞中钙离子含量和通量的快速变化
Biochem Biophys Res Commun. 1980 Jan 29;92(2):624-30. doi: 10.1016/0006-291x(80)90379-4.
4
Effects of vitamin A and its analogs (retinoids) on normal and neoplastic cells.维生素A及其类似物（类视黄醇）对正常细胞和肿瘤细胞的作用。
Biochim Biophys Acta. 1980 Mar 12;605(1):33-91. doi: 10.1016/0304-419x(80)90021-9.
5
Retinoids specifically enhance the number of epidermal growth factor receptors.维甲酸特异性地增加表皮生长因子受体的数量。
Nature. 1980 Apr 17;284(5757):626-9. doi: 10.1038/284626a0.
6
Structure and activity of diphtheria toxin. II. Attack by trypsin at a specific site within the intact toxin molecule.白喉毒素的结构与活性。II. 胰蛋白酶对完整毒素分子内特定位点的作用。
J Biol Chem. 1971 Mar 10;246(5):1504-10.
7
Cellular interactions of phorbol myristate acetate in tumor promotion.佛波醇肉豆蔻酸酯乙酸盐在肿瘤促进中的细胞相互作用。
Chem Biol Interact. 1971 Nov;3(6):401-11. doi: 10.1016/0009-2797(71)90001-9.
8
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9
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10
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Biochem J. 1969 Jun;113(2):299-305. doi: 10.1042/bj1130299.
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