二甲基亚砜可保护细胞免受多肽毒素和脊髓灰质炎病毒的侵害。
Dimethyl sulphoxide protects cells against polypeptide toxins and poliovirus.
作者信息
Sandvig K, Madshus I H, Olsnes S
出版信息
Biochem J. 1984 May 1;219(3):935-40. doi: 10.1042/bj2190935.
Abstract
The effect of dimethyl sulphoxide and other cryoprotective compounds on the sensitivity of cells to polypeptide toxins and to poliovirus was tested. In the presence of these compounds, which all affect membrane fluidity, the cells were protected against the toxic proteins and against poliovirus. The large protection obtained was not due to reduced binding and endocytosis of the toxins. Apparently, the cryoprotective compounds interfere with the entry of toxins and of the poliovirus genome across the cell membrane.
摘要
测试了二甲基亚砜及其他冷冻保护化合物对细胞对多肽毒素和脊髓灰质炎病毒敏感性的影响。在这些均会影响膜流动性的化合物存在的情况下，细胞受到保护，免受毒性蛋白和脊髓灰质炎病毒的侵害。所获得的显著保护作用并非由于毒素的结合和内吞作用减少。显然，冷冻保护化合物会干扰毒素和脊髓灰质炎病毒基因组穿过细胞膜的进入过程。
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