兔肾髓质亚细胞组分中的前列腺素生物合成与脂肪分解
Prostaglandin biosynthesis and lipolysis in subcellular fractions from rabbit kidney medulla.
作者信息
Erman A, Raz A
出版信息
Biochem J. 1981 Mar 15;194(3):957-61. doi: 10.1042/bj1940957.
Abstract
Three separate prostaglandin-generating activities are associated with plasma membranes, mitochondria and microsomal fractions from rabbit kidney medulla. In the plasma membranes and mitochondria, but not in microsomal fractions, Ca2+ ions stimulate the activity of phospholipase A2, yielding selective release of arachidonic acid and linoleic acid and concomitant increase in prostaglandin E2 formation.
摘要
兔肾髓质的质膜、线粒体和微粒体部分存在三种不同的前列腺素生成活性。在质膜和线粒体中，而非微粒体部分，钙离子可刺激磷脂酶A2的活性，导致花生四烯酸和亚油酸的选择性释放，并伴随前列腺素E2生成增加。
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