吡哆醇对兔肾髓质切片中前列腺素合成的影响。

Effect of pyridoxine on prostaglandin synthesis in rabbit kidney medulla slices.

作者信息

Fujimoto Y, Nishioka K, Ohtani N, Aihara M, Fujita T

出版信息

J Pharm Pharmacol. 1987 Apr;39(4):314-5. doi: 10.1111/j.2042-7158.1987.tb06276.x.

DOI:10.1111/j.2042-7158.1987.tb06276.x

Abstract

Pyridoxine stimulated the generation of prostaglandin E2 in rabbit kidney medulla slices. Moreover, pyridoxine in the presence of aspirin reduced the release of linoleic acid, but enhanced the release of arachidonic acid from the medulla slices as compared with aspirin alone, indicating that the enhancement of prostaglandin E2 formation elicited by pyridoxine may be ascribed to an increased conversion of linoleic acid to arachidonic acid. These results suggest that pyridoxine can be an important modulating factor in prostaglandin synthesis by the kidney.

摘要

吡哆醇刺激兔肾髓质切片中前列腺素E2的生成。此外，与单独使用阿司匹林相比，吡哆醇在阿司匹林存在的情况下可减少亚油酸的释放，但会增强肾髓质切片中花生四烯酸的释放，这表明吡哆醇引起的前列腺素E2生成增强可能归因于亚油酸向花生四烯酸转化的增加。这些结果表明，吡哆醇可能是肾脏前列腺素合成中的一个重要调节因子。