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Nickel carbonate induces DNA-protein crosslinks and DNA strand breaks in rat kidney.

作者信息

Ciccarelli R B, Hampton T H, Jennette K W

出版信息

Cancer Lett. 1981 May;12(4):349-54. doi: 10.1016/0304-3835(81)90178-6.

DOI:10.1016/0304-3835(81)90178-6
PMID:7306939
Abstract

DNA lesions were observed in kidney nuclei isolated from rats 20 h after i.p. injection with nickel carbonate. Dose-dependent, nickel-induced DNA crosslinks and DNA single strand breaks were detected using the alkaline elution technique. The DNA crosslinks were determined to be completely DNA-protein in nature. The DNA damage induced by nickel carbonate is discussed relative to the carcinogenicity of nickel compounds.

摘要

相似文献

1
Nickel carbonate induces DNA-protein crosslinks and DNA strand breaks in rat kidney.
Cancer Lett. 1981 May;12(4):349-54. doi: 10.1016/0304-3835(81)90178-6.
2
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2
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镍致癌性与职业性肺癌的风险评估
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6
Investigations of the frequency of DNA strand breakage and cross-linking and of sister chromatid exchange in the lymphocytes of electric welders exposed to chromium- and nickel-containing fumes.对暴露于含铬和镍烟雾的电焊工淋巴细胞中DNA链断裂和交联频率以及姐妹染色单体交换情况的调查。
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