Nickel carbonate induces DNA-protein crosslinks and DNA strand breaks in rat kidney.
作者信息
Ciccarelli R B, Hampton T H, Jennette K W
出版信息
Cancer Lett. 1981 May;12(4):349-54. doi: 10.1016/0304-3835(81)90178-6.
PMID:7306939
Abstract
DNA lesions were observed in kidney nuclei isolated from rats 20 h after i.p. injection with nickel carbonate. Dose-dependent, nickel-induced DNA crosslinks and DNA single strand breaks were detected using the alkaline elution technique. The DNA crosslinks were determined to be completely DNA-protein in nature. The DNA damage induced by nickel carbonate is discussed relative to the carcinogenicity of nickel compounds.
摘要
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