Promotion of carcinomas by repeated abrasion in initiated skin of mice.

Repeated abrasion of the skin of Sencar mice initiated with 100 nmol of dimethylbenzanthracene resulted in the appearance of carcinomas in addition to papillomas. These results strongly support the argument that repeated epidermal regeneration is a sufficient stimulus for the promotion of both benign and malignant neoplasms in the skin of mice.