Argyris T S
J Invest Dermatol. 1980 Oct;75(4):360-2. doi: 10.1111/1523-1747.ep12531153.
Regenerative epidermal hyperplasia produced by repeated abrasion every 21 days of the skin of female mice after initiation with 7, 12-dimethylbenz(a)anthracene results in the appearance of epidermal tumors. Full thickness wounds, approximately 2 cm in length, made every 14 days in mouse skin initiated with 7, 12-dimethylbenz(a)anthracene also results in the appearance of epidermal tumors adjacent to the wound edge. Repeated abrasion or wounding of normal female mouse skin does not result in the appearance of epidermal tumors. Repeated plucking of initiated mouse skin, which produces a milder epidermal hyperplasia than abrasion, does not result in the appearance of tumors. The data demonstrate that regenerative epidermal hyperplasia, of a sufficient intensity, can act as a tumor promoter.
在用7,12 - 二甲基苯并(a)蒽引发后，每21天对雌性小鼠皮肤进行一次反复擦伤所产生的再生性表皮增生会导致表皮肿瘤的出现。在用7,12 - 二甲基苯并(a)蒽引发的小鼠皮肤上，每14天制造一次长度约为2厘米的全层伤口，也会导致伤口边缘出现表皮肿瘤。对正常雌性小鼠皮肤进行反复擦伤或创伤不会导致表皮肿瘤的出现。对引发后的小鼠皮肤进行反复拔毛，其产生的表皮增生程度比擦伤轻，也不会导致肿瘤的出现。这些数据表明，足够强度的再生性表皮增生可作为肿瘤促进剂。
