Sommer-Tsilenis E, Kruse H P, Kuhlencordt F
Dtsch Med Wochenschr. 1981 Dec 4;106(49):1649-53. doi: 10.1055/s-2008-1070571.
Plasma concentrations of 25-hydroxyvitamin D (25-OH-D) were determined in 40 healthy persons and in patients with primary osteoporosis (n = 43), primary hyperparathyroidism (n = 19), intestinal osteopathy (n = 13), and after small intestine bypass operations (n = 8). The control group showed physiologic seasonal variations which must be taken into account in the individual case. Whereas there were no deviations from the normal in patients with osteoporosis, significantly lower values were obtained in the other disease groups. Estimation of 25-OH-D in plasma represents a valuable contribution for the diagnosis of generalized osteopathies and for the differential diagnosis of hypercalcaemia. In addition, the effects of vitamin D treatment may be objectively assessed. Overdosage and intoxication may be recognized in time.
对40名健康人以及患有原发性骨质疏松症（43例）、原发性甲状旁腺功能亢进症（19例）、肠道骨病（13例）和小肠旁路手术后（8例）的患者测定了血浆25-羟维生素D（25-OH-D）浓度。对照组呈现出生理性季节变化，在个别病例中必须予以考虑。骨质疏松症患者的血浆浓度无异常，而其他疾病组的值则明显较低。血浆中25-OH-D的测定对全身性骨病的诊断以及高钙血症的鉴别诊断有重要意义。此外，还可客观评估维生素D治疗的效果。可及时发现过量用药和中毒情况。
