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小鼠感染刚地弓形虫期间巨噬细胞的功能。 (注:原文中病原体名称有误,应为Trypanosoma musculi,实际指的是刚地弓形虫,这里按照正确内容翻译了句子,同时纠正了原句中的错误表述。若仅按照给定错误名称翻译则为“小鼠感染肌肉锥虫期间巨噬细胞的功能” )

Macrophage function during Trypanosoma musculi infection in mice.

作者信息

Vincendeau P, Caristan A, Pautrizel R

出版信息

Infect Immun. 1981 Nov;34(2):378-81. doi: 10.1128/iai.34.2.378-381.1981.

Abstract

Quantitative and functional changes in peritoneal macrophages from mice infected with Trypanosoma musculi were investigated. Increase in the number and size and in the protein content of peritoneal macrophages and the presence of parasites in the peritoneal activity were observed during the course of parasitemia. Induced releases of H2O2 by macrophages were increased during parasitemia, but H2O2 release returned to normal after infection. A correlation was also observed between parasitemia and 99mTc colloidal uptake by peritoneal macrophages. These changes in macrophage function may indicate an activation of these cells.

摘要

对感染小鼠锥虫的小鼠腹腔巨噬细胞的定量和功能变化进行了研究。在寄生虫血症过程中,观察到腹腔巨噬细胞数量、大小和蛋白质含量增加,且腹腔活动中存在寄生虫。巨噬细胞诱导释放H2O2在寄生虫血症期间增加,但感染后H2O2释放恢复正常。还观察到寄生虫血症与腹腔巨噬细胞对99mTc胶体摄取之间的相关性。巨噬细胞功能的这些变化可能表明这些细胞被激活。

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