Pirch J H, Peterson S L
Int J Neurosci. 1981;15(3):141-6. doi: 10.3109/00207458108985906.
Event-related slow potentials and single unit activity were recorded from frontal cortex of unanesthetized, restrained rats trained to associate an auditory cue with rewarding medial forebrain bundle (MFB) stimulation. The majority of cortical units demonstrated an alteration of firing rate after the cue, with the predominant response being excitatory. The patterns of unit response during the interval between the cue and reinforcement varied considerable and few units showed a pattern which coincided temporally with the wave forms of the negative slow potential responses. These results indicate that negative cortical slow potential responses to meaningful stimuli are associated with an overall increase in activity of cortical neurons.
在未麻醉、受约束且经过训练将听觉提示与奖励性内侧前脑束（MFB）刺激相关联的大鼠额叶皮层记录事件相关慢电位和单单位活动。大多数皮层单位在提示后表现出放电率的改变，主要反应为兴奋性。提示与强化之间间隔期间的单位反应模式差异很大，很少有单位表现出与负性慢电位反应波形在时间上一致的模式。这些结果表明，皮层对有意义刺激的负性慢电位反应与皮层神经元活动的总体增加有关。
